2. Metabolic Enzyme/Protease Immunology/Inflammation
  3. Dihydroorotate Dehydrogenase Interleukin Related FXR
  4. Vidofludimus hemicalcium

Vidofludimus hemicalcium  (Synonyms: 4sc-101 hemicalcium; SC12267 hemicalcium)

Cat. No.: HY-14908A
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Vidofludimus (4sc-101; SC12267) hemicalcium is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus hemicalcium, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus hemicalcium also can be used for the research of fatty liver by targeting FXR.

For research use only. We do not sell to patients.

Vidofludimus hemicalcium Chemical Structure

Vidofludimus hemicalcium Chemical Structure

CAS No. : 1354012-90-0

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Vidofludimus hemicalcium Related Antibodies

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Description

Vidofludimus (4sc-101; SC12267) hemicalcium is an orally active inhibitor for dihydroorotate dehydrogenase (DHODH) and also is a novel modulator for farnesoid X receptor (FXR). Vidofludimus hemicalcium, as an immunomodulatory agent, can be used for the research of autoimmune disorders such as inflammatory bowel disease (IBD). Vidofludimus hemicalcium also can be used for the research of fatty liver by targeting FXR[1][2][3].

IC50 & Target

EC50: 450 nM (FXR)[1]
IC50: 160 nM (human DHODH)[3]
In Vitro

Vidofludimus hemicalcium (0-1 µM) selectively activats FXR in a concentration dependent manner with an EC50 value of about 450 nM in inducing the recruitment of various coactivator LXXLL motifs[1].
Vidofludimus hemicalcium (0-8 μM) blocks nuclear translocation of p65 by suppressing IKK-IκB-NF-κB pathway[1].
Vidofludimus hemicalcium has inhibitory activity for human DHODH with an IC50 value of 160 nM[2].
Vidofludimus hemicalcium inhibits dihydro-orotate dehydrogenase and lymphocyte proliferation in vitro[3].
Vidofludimus hemicalcium inhibits interleukin (IL)-17 secretion in vitro independently of effects on lymphocyte proliferation[3].
Vidofludimus hemicalcium completely blocks IL-23 + IL-1β-stimulated secretion of IL-17 by colonic strips in ex vivo[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Vidofludimus hemicalcium Related Antibodies
In Vivo

"Vidofludimus hemicalcium (i.p.; once daily; for 14 days) exerts effects on dextran sodium sulfate (DSS) induced colitis in an FXR-dependent manner in vivo[1].
Vidofludimus hemicalcium (p.o; 60 mg/kg; for 6 days) effectively improves many parameters of TNBS-induced colitis in rats and has inhibitory effects on colonic STAT3 and IL-17[3]."

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

375.40

Formula

C20H18FNO4.1/2Ca
CAS No.
SMILES

O=C(C1=C(C(NC2=CC=C(C3=CC=CC(OC)=C3)C=C2F)=O)CCC1)O.[Ca].[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Vidofludimus hemicalcium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vidofludimus hemicalcium1354012-90-04sc-101 hemicalciumSC12267 hemicalciumDihydroorotate DehydrogenaseInterleukin RelatedFXRDHODHILNR1H4oralnon-alcoholic fatty liver disease (NAFLD)dihydroorotate dehydrogenase (DHODH)farnesoid X receptor (FXR)immunomodulatoryinflammatory bowel disease (IBD)fatty liverInhibitorinhibitorinhibit

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