1. GPCR/G Protein
  2. Adenylate Cyclase
  3. α-Melanocyte-Stimulating Hormone (MSH), amide

α-Melanocyte-Stimulating Hormone (MSH), amide 

Cat. No.: HY-P0252 Purity: 98.02%
Handling Instructions

α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-Melanocyte-Stimulating Hormone (MSH), amide Chemical Structure

α-Melanocyte-Stimulating Hormone (MSH), amide Chemical Structure

CAS No. : 581-05-5

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1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 312 In-stock
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25 mg USD 672 In-stock
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Description

α-Melanocyte-Stimulating Hormone (MSH), amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.

IC50 & Target

Melanocortin 1 receptor[1]
Adenylyl cyclase[1]

In Vitro

α-Melanocyte-Stimulating Hormone (MSH), amide is an ancient tridecapeptide with potent inhibitory activity in all major forms of inflammation. α-Melanocyte-stimulating hormone (α-MSH) acts as an anti-inflammatory agent via down regulating the production and activity of the pro-inflammatory cytokines interleukin-1 (IL-1), tumor necrosis factor (TNF)-α and IL-6 expressed in various cells of the immune system. It also controls the nitric oxide production associated with inflammation. α−MSH inhibits nuclear factor-κB (NF-κB)-dependent gene transcription and NF-κB pathway induced by TNF and other inflammatory agents. This activity of α-MSH is mediated through the production of cyclic adenosine monophosphate (cAMP) and activation of protein kinase A (PKA) enzyme. α–MSH functions as a potent therapeutics for various conditions resulted through NF-κB activation including, inflammatory diseases, human immunodeficiency virus (HIV) replication in AIDS (acquired immunodeficiency syndrome), and septic shock[2].

In Vivo

α-Melanocyte-Stimulating Hormone (MSH), amide (α-MSH) has an essential role to play in melanin production in animals. α-MSH regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases[2].

Molecular Weight

1664.88

Formula

C₇₇H₁₀₉N₂₁O₁₉S

CAS No.

581-05-5

Sequence

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Sequence Shortening

Ac-SYSMEHFRWGKPV-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (30.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6006 mL 3.0032 mL 6.0064 mL
5 mM 0.1201 mL 0.6006 mL 1.2013 mL
10 mM 0.0601 mL 0.3003 mL 0.6006 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

α-Melanocyte-Stimulating Hormone (MSH), amideAdenylate CyclaseAdenylyl cyclaseInhibitorinhibitorinhibit

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Product Name:
α-Melanocyte-Stimulating Hormone (MSH), amide
Cat. No.:
HY-P0252
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