1. GPCR/G Protein Neuronal Signaling
  2. Melanocortin Receptor
  3. α-MSH

α-MSH  (Synonyms: α-Melanocyte-Stimulating Hormone)

Cat. No.: HY-P0252 Purity: 98.43%
COA Handling Instructions

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

α-MSH Chemical Structure

α-MSH Chemical Structure

CAS No. : 581-05-5

Size Price Stock Quantity
1 mg USD 66 In-stock
5 mg USD 198 In-stock
10 mg USD 343 In-stock
25 mg USD 739 In-stock
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of α-MSH:

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Description

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].

IC50 & Target

MC4R

 

In Vitro

α-MSH modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH modulates NFκB activation. α-MSH inhibits translocation of transcription factor κB to the nucleus[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

α-MSH (50 μg/0.2 ml saline; i.p.) given systemically effectively modulates inflammatory reactions[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IL-10–deficient mice[3]
Dosage: 50 µg/0.2 ml saline
Administration: I.p.
Result: Given systemically effectively modulated inflammatory reactions.
Molecular Weight

1664.88

Formula

C77H109N21O19S

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

Sequence Shortening

Ac-SYSMEHFRWGKPV-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (60.06 mM; Need ultrasonic)

H2O : ≥ 12.5 mg/mL (7.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6006 mL 3.0032 mL 6.0064 mL
5 mM 0.1201 mL 0.6006 mL 1.2013 mL
10 mM 0.0601 mL 0.3003 mL 0.6006 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.43%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
α-MSH
Cat. No.:
HY-P0252
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