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α-MSH

(Synonyms: α-Melanocyte-Stimulating Hormone)
24 Cited Publications
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Based on 24 publication(s) in Google Scholar

α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC).

For research use only. We do not sell to patients.

  • Purity: 99.98%
  • CAS No.: 581-05-5
  • Formula: C77H109N21O19S
  • Molecular Weight:1664.88
  • Storage:

    Sealed storage, away from moisture and light, under nitrogen.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

  • α-MSH Chemical Structure
    α-MSH Chemical Structure
  • Experimental Validation Results for α-MSH
  • Experimental Validation Results for α-MSH
  • Experimental Validation Results for α-MSH
  • Experimental Validation Results for α-MSH
  • Experimental Validation Results for α-MSH
CAS No.: 581-05-5
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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WBCell Proliferation/Viability AssayBio/Physico-chemical AssayFlow CytometryRT-PCR
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  • Cell Proliferation/Viability Assay
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All Melanocortin Receptor Isoforms

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  • α-MSH Chemical Structure
    α-MSH Chemical Structure
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    α-MSH purchased from MedChemExpress. Usage Cited in: Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979. [Abstract]

    Customer Validation
     α-MSH (0.3 μmol/L; 72 h). Effects of PT8 on the expression of cAMP signaling pathway-related factors in B16 cells. Relative quantification of MITF mRNA levels through quantitative PCR after treatment with PT8.

  • 1/16

    α-MSH purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 May 15:470:134112. [Abstract]

    Customer Validation
     α-MSH (0.1  μM; 48  h). Number of B16-F10 cells. Positive group: α-MSH.

  • 1/16

    α-MSH purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 15;14(1):5740. [Abstract]

    Customer Validation
     Western blotting of the indicated proteins in B16F10-dCas9 cells transduced with NTC sgRNA or Mc1r sgRNA. Cells were untreated or treated with 1  µM α-MSH (1  µM; 1  h) for 1  h. A representative result is shown from two independent experiments.

  • 1/16

    α-MSH purchased from MedChemExpress. Usage Cited in: Blood Adv. 2023 Jul 11;7(13):3199-3212. [Abstract]

    Customer Validation
     α-MSH (1 mg/kg; i.p.; once a day for a total of 7 days). Cell cycle analysis of LT-HSCs from the BM of WT mice treated with saline or α-MSH along with vehicle, MK-2206, or PD325901 (n = 6).

  • 1/16

    α-MSH purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Sep 10;12(1):501. [Abstract]

    Customer Validation
     α-MSH (200 nM; 48 h). The effects of hAMSC-CM or hAESC-CM on tyrosinase enzyme activity are confirmed by treatment with L-DOPA and detection of tyrosinase at 475 nm.

  • α-MSH