α-MSH TFA
Based on 23 publication(s) in Google Scholar
α-MSH (α-Melanocyte-Stimulating Hormone) TFA, an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH TFA is a post-translational derivative of pro-opiomelanocortin (POMC).
For research use only. We do not sell to patients.
- Purity: 98.54%
- CAS No.: 171869-93-5
- Formula: C77H109N21O19S.xC2HF3O2
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-MSH TFA
More- Nat Commun. 2023 Sep 15;14(1):5740. [Abstract]
- J Hazard Mater. 2024 May 15:470:134112. [Abstract]
- Acta Pharmacol Sin. 2025 Jul;46(7):1892-1904. [Abstract]
- Phytomedicine. 2026 Apr:153:157963. [Abstract]
- Free Radic Biol Med. 2021 Nov 20:176:392-405. [Abstract]
- Stem Cell Res Ther. 2021 Sep 10;12(1):501. [Abstract]
- Blood Adv. 2023 Jul 11;7(13):3199-3212. [Abstract]
- J Med Chem. 2024 Nov 14;67(21):19323-19341. [Abstract]
- Postharvest Biol Technol. 2024 Feb, 208, 112645.
- Antioxidants (Basel). 2026 Mar 11;15(3):350. [Abstract]
- Antioxidants (Basel). 2022 Jul 2;11(7):1317. [Abstract]
- J Agric Food Chem. 2023 Nov 1;71(43):16090-16101. [Abstract]
- Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979. [Abstract]
- J Ethnopharmacol. 2024 May 23:326:117933. [Abstract]
- Foods. 2026 Feb 1;15(3):507. [Abstract]
- Bioorg Chem. 2024 Aug 25:152:107758. [Abstract]
- Algal Res. 2025 Jun.
- J Photochem Photobiol B. 2025 Nov:272:113277. [Abstract]
- Heliyon. 2024 Aug 7;10(15):e35295. [Abstract]
- Photochem Photobiol Sci. 2025 Oct;24(10):1763-1779. [Abstract]
- Int J Cosmet Sci. 2025 Feb;47(1):31-44. [Abstract]
- J Cosmet Dermatol. 2023 Oct;22(10):2824-2830. [Abstract]
- Journal of Dermatologic Science and Cosmetic Technology. 2025 Jan 11.
Customer Validation & Images
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RT-PCR
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Cell Proliferation/Viability Assay
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WB
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Flow Cytometry
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Bio/Physico-chemical Assay
Biological Activity
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MC4R |
α-MSH TFA modulates CNS inflammation by acting directly on melanocortin receptors in glial cells. α-MSH TFA modulates NFκB activation. α-MSH TFA inhibits translocation of transcription factor κB to the nucleus[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Ac-SYSMEHFRWGKPV-NH2
Chemical Information
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CAS No. 171869-93-5
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Appearance Solid
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Formula C77H109N21O19S.xC2HF3O2
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Color White to off-white
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Synonyms
α-Melanocyte-Stimulating Hormone TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (23)
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Journal Impact Factor
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Most Recent
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Nat Commun
Activation of melanocortin-1 receptor signaling in melanoma cells impairs T cell infiltration to dampen antitumor immunity. [Abstract]2023 Sep 15;14(1):5740. PMID: 37714844
α-MSH TFA purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Sep 15;14(1):5740. [Abstract]
Western blotting of the indicated proteins in B16F10-dCas9 cells transduced with NTC sgRNA or Mc1r sgRNA. Cells were untreated or treated with 1 µM α-MSH (1 µM; 1 h) for 1 h. A representative result is shown from two independent experiments.
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J Hazard Mater
Melanin-mediated accumulation of polycyclic aromatic hydrocarbons in human hair: Insights from biomonitoring and cell exposure studies. [Abstract]2024 May 15:470:134112. PMID: 38537572
α-MSH TFA purchased from MedChemExpress. Usage Cited in: J Hazard Mater. 2024 May 15:470:134112. [Abstract]
α-MSH (0.1 μM; 48 h). Number of B16-F10 cells. Positive group: α-MSH.
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Acta Pharmacol Sin
Dorsal raphe GABA-ergic neurons regulate the susceptibility to social transfer of pain in mice. [Abstract]2025 Jul;46(7):1892-1904. PMID: 40011629 -
Phytomedicine
Clematis Tangutica (Maxim.) Korsh. extracts promote melanogenesis via PKA/CREB activation and multi-cytokine inhibition: A novel dual targeting strategy for vitiligo therapy. [Abstract]2026 Apr:153:157963. PMID: 41720011 -
Free Radic Biol Med
The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis. [Abstract]2021 Nov 20:176:392-405. PMID: 34560247 -
Stem Cell Res Ther
Human amniotic stem cells-derived exosmal miR-181a-5p and miR-199a inhibit melanogenesis and promote melanosome degradation in skin hyperpigmentation, respectively. [Abstract]2021 Sep 10;12(1):501. PMID: 34507619
α-MSH TFA purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2021 Sep 10;12(1):501. [Abstract]
α-MSH (200 nM; 48 h). The effects of hAMSC-CM or hAESC-CM on tyrosinase enzyme activity are confirmed by treatment with L-DOPA and detection of tyrosinase at 475 nm.
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Blood Adv
Melanocortin/MC5R axis regulates the proliferation of hematopoietic stem cells in mice after ionizing radiation injury. [Abstract]2023 Jul 11;7(13):3199-3212. PMID: 36920787
α-MSH TFA purchased from MedChemExpress. Usage Cited in: Blood Adv. 2023 Jul 11;7(13):3199-3212. [Abstract]
α-MSH (1 mg/kg; i.p.; once a day for a total of 7 days). Cell cycle analysis of LT-HSCs from the BM of WT mice treated with saline or α-MSH along with vehicle, MK-2206, or PD325901 (n = 6).
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J Med Chem
Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo. [Abstract]2024 Nov 14;67(21):19323-19341. PMID: 39485487 -
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Antioxidants (Basel)
Natural Bioactive Peptides from Tree Peony Flowers: Multifunctional Effects on Skin Antioxidation, Wrinkle Reduction, Moisturization, and Melanin Inhibition. [Abstract]2026 Mar 11;15(3):350. PMID: 41897496 -
Antioxidants (Basel)
Antioxidative Role of Hygrophila erecta (Brum. F.) Hochr. on UV-Induced Photoaging of Dermal Fibroblasts and Melanoma Cells. [Abstract]2022 Jul 2;11(7):1317. PMID: 35883808 -
J Agric Food Chem
2023 Nov 1;71(43):16090-16101. PMID: 37856847 -
Colloids Surf B Biointerfaces
Glabridin-encapsulated liposomes targeting melanocytes through the melanocortin 1 receptor. [Abstract]2025 Jul 24:255:114979. PMID: 40712492
α-MSH TFA purchased from MedChemExpress. Usage Cited in: Colloids Surf B Biointerfaces. 2025 Jul 24:255:114979. [Abstract]
α-MSH (0.3 μmol/L; 72 h). Effects of PT8 on the expression of cAMP signaling pathway-related factors in B16 cells. Relative quantification of MITF mRNA levels through quantitative PCR after treatment with PT8.
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J Ethnopharmacol
The whitening effect of cuscutin responsible for traditional use of Bergenia purpurascens. [Abstract]2024 May 23:326:117933. PMID: 38382653 -
Foods
Enzymatic Production of Collagen Oligopeptides from Porcine Skin and Their Structure-Activity Relationships in Anti-Aging and Skin-Whitening Effect. [Abstract]2026 Feb 1;15(3):507. PMID: 41683092 -
Bioorg Chem
Melanin resistance of heat-processed ginsenosides from Panax ginseng berry treated with citric acid through autophagy pathway. [Abstract]2024 Aug 25:152:107758. PMID: 39216197 -
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J Photochem Photobiol B
3, 7-dihydroxy-2, 4-dimethoxyphenanthrene protects against UVB-induced skin hyperpigmentation via antioxidant and anti-melanogenic mechanisms. [Abstract]2025 Nov:272:113277. PMID: 41106058 -
Heliyon
Differentiation of cultured hair follicle neural crest stem cells into functional melanocytes. [Abstract]2024 Aug 7;10(15):e35295. PMID: 39170163 -
Photochem Photobiol Sci
The extract of dendrobium Coelonin inhibits PIH induced by AFR CO2 fractional laser combined with UV-B. [Abstract]2025 Oct;24(10):1763-1779. PMID: 41108468 -
Int J Cosmet Sci
Hydrolyzed conchiolin protein inhibits melanogenesis through PKA/CREB and MEK/ERK signalling pathways. [Abstract]2025 Feb;47(1):31-44. PMID: 39128885 -
J Cosmet Dermatol
Paeoniflorin found in Paeonia lactiflora root extract inhibits melanogenesis by regulating melanin-related signal transduction in B16F10 cells. [Abstract]2023 Oct;22(10):2824-2830. PMID: 37288793 -
Solvent & Solubility
H2O : 25 mg/mL (Need ultrasonic)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. [Content Brief]
[2]. 2. M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82. [Content Brief]
[3]. Lipton JM, et al. Mechanisms of antiinflammatory action of alpha-MSH peptides. In vivo and in vitro evidence. Ann N Y Acad Sci. 1999;885:173-182. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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