1. GPCR/G Protein
    Neuronal Signaling
  2. Melanocortin Receptor
  3. Bremelanotide Acetate

Bremelanotide Acetate (Synonyms: PT-141 Acetate)

Cat. No.: HY-18678A Purity: 99.97%
Handling Instructions

Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction.

For research use only. We do not sell to patients.

Bremelanotide Acetate Chemical Structure

Bremelanotide Acetate Chemical Structure

CAS No. : 1607799-13-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

Bremelanotide Acetate (PT-141 Acetate), a synthetic peptide analogue of α-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R for the treatment of sexual dysfunction[1].

In Vivo

Bremelanotide Acetate (50-200 μg/kg; s.c.; once) significantly increases proceptive solicitations in females primed with Estradiol benzoate+Progesterone or Estradiol benzoate alone in bilevel chambers[2].

Animal Model: Ovariectomized Long–Evans rats[2]
Dosage: 50, 100, 200 μg/kg
Administration: s.c.; once
Result: Significantly increased proceptive solicitations in females primed with Estradiol benzoate+Progesterone or Estradiol benzoate alone in bilevel chambers.
Clinical Trial
Molecular Weight

1085.22

Formula

C₅₂H₇₂N₁₄O₁₂

CAS No.

1607799-13-2

SMILES

O=C(N[[email protected]](CCCCNC(C[[email protected]@H]1NC([[email protected]@H](NC(C)=O)CCCC)=O)=O)([H])C(O)=O)[[email protected]@H](NC([[email protected]@H](NC([[email protected]@](NC([[email protected]@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45.OC(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (33.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9215 mL 4.6074 mL 9.2147 mL
5 mM 0.1843 mL 0.9215 mL 1.8429 mL
10 mM 0.0921 mL 0.4607 mL 0.9215 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (1.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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Keywords:

BremelanotidePT-141PT141PT 141Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

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Bremelanotide Acetate
Cat. No.:
HY-18678A
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