2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Bremelanotide

Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Bremelanotide

Bremelanotide Chemical Structure

CAS No. : 189691-06-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Bremelanotide:

Bremelanotide Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bremelanotide

View All Melanocortin Receptor Isoform Specific Products:

View All Isoforms
MC1R MC3R MC2R MC4R MC5R

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders[1][2][3].

IC50 & Target[3]

MC4R

 

MC3R

 

In Vitro

Bremelanotide (10−3-105 nM) binds to MC3R and MC4R in a concentration-dependent manner[3].
Bremelanotide induces cAMP accumulation in cell-free assays with EC50 values of 0.4 nM for MC3R and 0.2 nM for MC4R[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bremelanotide Related Antibodies
In Vivo

Bremelanotide (50-200 μg/kg; s.c.) selectively increases appetitive sexual behaviors (solicitations, hops and darts) in hormone-primed ovariectomized female rats via activation of MC4R and dopamine release in the medial preoptic area[1].
Bremelanotide (0.01-10 mg/kg; i.p.; single dose) induces dose-dependent repetitive grooming behavior in male and female mice, with 1 mg/kg being the lowest effective grooming dose that does not cause anxiety-like behavior[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female rats (ovariectomized, hormone-primed with estradiol and progesterone, or estradiol alone)[1]
Dosage: 50, 100, 200 μg/kg
Administration: Subcutaneously injection
Result: Increased solicitations in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Increased solicitations in estradiol-alone primed rats at 200 μg/kg.
Increased hops and darts in estradiol + progesterone-primed rats at 100 and 200 μg/kg.
Induced female mounting behavior at 200 μg/kg.
Molecular Weight

1025.16

Formula

C50H68N14O10
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (97.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9755 mL 4.8773 mL 9.7546 mL
5 mM 0.1951 mL 0.9755 mL 1.9509 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.69%

SDS (393 KB)

COA (253 KB) RP-HPLC (110 KB) MS (222 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9755 mL 4.8773 mL 9.7546 mL 24.3864 mL
5 mM 0.1951 mL 0.9755 mL 1.9509 mL 4.8773 mL
10 mM 0.0975 mL 0.4877 mL 0.9755 mL 2.4386 mL
15 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6258 mL
20 mM 0.0488 mL 0.2439 mL 0.4877 mL 1.2193 mL
25 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9755 mL
30 mM 0.0325 mL 0.1626 mL 0.3252 mL 0.8129 mL
40 mM 0.0244 mL 0.1219 mL 0.2439 mL 0.6097 mL
50 mM 0.0195 mL 0.0975 mL 0.1951 mL 0.4877 mL
60 mM 0.0163 mL 0.0813 mL 0.1626 mL 0.4064 mL
80 mM 0.0122 mL 0.0610 mL 0.1219 mL 0.3048 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Bremelanotide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bremelanotide189691-06-3PT-141PT141PT 141Melanocortin ReceptorMC Receptormelanocortin receptorMC2RMC4Rhypoactive sexual desire disordersInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Bremelanotide
Cat. No.:
HY-18678
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.