189691-06-3
Chemical Structure
Bremelanotide
Synonym(s): PT-141
- CAS No.: 189691-06-3
- Formula:C50H68N14O10
- Molecular Weight:1025.16
IUPAC Name: (3S,6S,9R,12S,15S,23S)-12-((1H-imidazol-5-yl)methyl)-3-((1H-indol-3-yl)methyl)-15-((S)-2-acetamidohexanamido)-9-benzyl-6-(3-guanidinopropyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid
InChIKey: FFHBJDQSGDNCIV-MFVUMRCOSA-N
SMILES: O=C(N[C@](CCCCNC(C[C@@H]1NC([C@@H](NC(C)=O)CCCC)=O)=O)([H])C(O)=O)[C@@H](NC([C@@H](NC([C@@](NC([C@@H](NC1=O)CC2=CN=CN2)=O)([H])CC3=CC=CC=C3)=O)CCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45
Biological Activity: Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders[1][2][3].
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Bremelanotide | 99.94% | Bremelanotide (PT-141) is a melanocortin receptor agonist. Bremelanotide can activate MC4R and increases dopamine release. Bremelanotide induces appetitive sexual behaviors, female mounting behavior, and repetitive self-grooming. Bremelanotide can be used for the research of hypoactive sexual desire disorders. | ||||||||||||||||||||
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References
- [1]. Pfaus J, et al. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007;4 Suppl 4:269-279. [Content Brief]
- [2]. Harberson M T, et al. Bremelanotide, a Medication for Hypoactive Sexual Desire Disorder, Promotes Repetitive Self-grooming and Avoidance Behavior in Mice[D]. The University of Toledo, 2024.
- [3]. Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102. [Content Brief]
