hMC1R agonist 1
Based on 1 Customer Validation
hMC1R agonist 1 is a selective hMC1R agonist. hMC1R agonist 1 activates adenylate cyclase to induce intracellular cAMP accumulation. hMC1R agonist 1 can be used for the research of immune-inflammatory disorders.
For research use only. We do not sell to patients.
- CAS No.: 3028881-87-7
- Formula: C54H70N14O8S2
- Molecular Weight:1107.35
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Storage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MC1R |
hMC1R agonist 1 (Compound 5) (0.1 nM-10 μM binds to hMC1R (IC50 = 3.5 nM), hMC3R (IC50 = 32 nM), hMC4R (IC50 = 9.1 nM), and hMC5R (IC50 = 4.4 nM) in stably transfected HEK293 cells[1].
hMC1R agonist 1 acts as a full agonist for hMC1R (EC50 = 3.0 nM) in stably transfected HEK293 cells, having low activity to hMC3R (EC50 = 902 nM) and hMC4R (EC50 = 915 nM), with no measurable activity at hMC5R (EC50 >1000 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3028881-87-7
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Appearance Solid
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Molecular Weight 1107.35
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Formula C54H70N14O8S2
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Color White to off-white
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Sequence
metaXylene Ac-{Nle}-Cys-His-{d-Phe}-Arg-Trp-Cys-NH2
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Sequence Shortening
metaXylene Ac-{Nle}-CH-{d-Phe}-RWC-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (90.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9031 mL | 4.5153 mL | 9.0306 mL | 22.5764 mL |
| 5 mM | 0.1806 mL | 0.9031 mL | 1.8061 mL | 4.5153 mL | |
| 10 mM | 0.0903 mL | 0.4515 mL | 0.9031 mL | 2.2576 mL | |
| 15 mM | 0.0602 mL | 0.3010 mL | 0.6020 mL | 1.5051 mL | |
| 20 mM | 0.0452 mL | 0.2258 mL | 0.4515 mL | 1.1288 mL | |
| 25 mM | 0.0361 mL | 0.1806 mL | 0.3612 mL | 0.9031 mL | |
| 30 mM | 0.0301 mL | 0.1505 mL | 0.3010 mL | 0.7525 mL | |
| 40 mM | 0.0226 mL | 0.1129 mL | 0.2258 mL | 0.5644 mL | |
| 50 mM | 0.0181 mL | 0.0903 mL | 0.1806 mL | 0.4515 mL | |
| 60 mM | 0.0151 mL | 0.0753 mL | 0.1505 mL | 0.3763 mL | |
| 80 mM | 0.0113 mL | 0.0564 mL | 0.1129 mL | 0.2822 mL |
hMC1R agonist 1 Related Classifications
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