2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Melanotan (MT)-II acetate

Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction.

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Melanotan (MT)-II acetate

Melanotan (MT)-II acetate Chemical Structure

CAS No. : 1036322-26-5

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Description

Melanotan (MT)-II acetate is a melanocortin receptor agonist that crosses the blood-brain barrier. Melanotan (MT)-II acetate activates melanocortin receptor 3 and melanocortin receptor 4, and stimulates the release of central endogenous oxytocin. Melanotan (MT)-II acetate reverses recognition memory impairment, increased anxiety levels and reduced exploratory tendency in zebrafish exposed to short-term high-fat diet. Melanotan (MT)-II acetate improves impaired social behavior indicators in mouse models of autism spectrum disorder. Melanotan (MT)-II acetate induces weight loss, reduces food intake and exerts anorectic effects. Melanotan (MT)-II acetate increases intracavernous pressure and erectile activity in brown rats. Melanotan (MT)-II acetate can be used in studies related to memory impairment, anxiety, reduced exploratory behavior, autism spectrum disorder, obesity and erectile dysfunction[1][2][3][4].

IC50 & Target[1]

MC3R

 

MC4R

 

In Vivo

Melanotan (MT)-II (20 μM, percutaneous immersion for 2 consecutive days) acetate reverses high-fat diet-induced impairments in recognition memory, reduced exploratory behavior, and anxiety-like symptoms in zebrafish, restoring these indicators to levels comparable to those of animals fed a normal diet[1].
Melanotan (MT)-II (2.5 μg per day; intracerebroventricular injection; continuous infusion; 7 days) acetate rescues social ability deficits in adult male maternal immune activation (MIA) mice, increasing the social ability index score from 3.1 to 26.3[2].
Melanotan (MT)-II (0.1-1 nM, microinjected bilaterally into the nucleus accumbens) acetate significantly reduces 24-hour food intake in fasted C57BL/6J mice, produces a significant anorectic effect, and decreases feeding responses in ad libitum-fed mice[3].
Melanotan (MT)-II (0.1-1 mg/kg, intravenous injection) acetate significantly enhances the overall erectile activity in conscious rats and shortens the latency of the first erectile event in anesthetized rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Danio rerio, longfin phenotype (3-5 months old, ~50:50 male to female ratio, high-fat diet-induced model)[1]
Dosage: 20 μM
Administration: percutaneous immersion; two days
Result: Reversed the significant reduction in time spent in the red (reinforced) arm of the Y-maze (HF + MT-II group spent significantly more time than untreated HF group, matching control group levels).
Reversed the HF diet-induced increase in time spent in the Y-maze start arm (a marker of anxiety).
Restored total object exploration time in the one-trial memory test to control group levels.
Animal Model: C57BL/6J (4-6 month-old male; maternal immune activation model)[2]
Dosage: 2.5 μg/day
Administration: i.c.v.; continuous infusion; 7 days
Result: Increased sociability index score significantly from 3.1 to 26.3.
Did not produce a significant change in social novelty scores.
Animal Model: C57BL/6J (male, 2-3 months old, average body weight ~22 g, food-deprived for ~16 hours to induce food-motivated state)[3]
Dosage: 0.1, 0.3, 1 nM/side
Administration: bilateral microinjection into nucleus accumbens; single dose
Result: Significantly decreased food intake at 1, 2, and 4 hours post-injection compared to saline.
Significantly decreased food intake at 24 hours post-injection only at 0.3 nmol/side dose compared to saline.
Showed a significant main effect of drug, time, and drug-time interaction.
Animal Model: Sprague-Dawley (male, 225-250 g, telemetric intracavernosal pressure monitoring model)[4]
Dosage: 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg
Administration: i.v.
Result: Induced at least one penile erection in 4 out of 5 rats, with a mean 1.6 erections, mean latency to first erection of 2812 s, mean ICPmax of ~360 mmHg, mean AUC of ~2100 mmHg.s, and mean SUM AUC of ~3000 mmHg.s at 0.1 mg/kg.
Induced at least one penile erection in 4 out of 6 rats, with a mean 1.8 erections, mean latency to first erection of 2616 s, mean ICPmax of 472 mmHg, mean AUC of ~2200 mmHg.s, and mean SUM AUC of ~4000 mmHg.s at 0.3 mg/kg.
Induced at least one penile erection in 6 out of 8 rats, with a mean 4.8 erections, mean latency to first erection of 1780 s, mean ICPmax of 548 mmHg, mean AUC of ~2300 mmHg.s, and mean SUM AUC of 10653 mmHg.s at 1 mg/kg.
Molecular Weight

1084.23

Formula

C52H73N15O11
CAS No.
Sequence

Ac-{Nle}-Asp-His-{d-Phe}-Arg-Trp-Lys-NH2, (2→7)-lactam
Sequence Shortening

Ac-{Nle}-DH-{d-Phe}-RWK-NH2, (2→7)-lactam
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Keywords:

Melanotan (MT)-II1036322-26-5Melanocortin ReceptorMC ReceptorC57BL/6J micemelanocortin receptor 3nucleus accumbensmemory impairmenterectile dysfunctionratsautism spectrum disordermelanocortin receptor 4oxytocinzebrafishInhibitorinhibitorinhibit

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