Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2
Based on 1 Customer Validation
Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 819048-44-7
- Formula: C51H70N18O11S2
- Molecular Weight:1175.35
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Storage:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-115644
BMS-470539 dihydrochloride
Biological Activity
Chemical Information
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CAS No. 819048-44-7
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Appearance Solid
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Molecular Weight 1175.35
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Formula C51H70N18O11S2
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Color White to off-white
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Sequence
Ac-{d-Arg}-Cys-Glu-His-{d-Phe}-Arg-Trp-Cys-NH2 (Disulfide bridge: Cys2-Cys8)
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Sequence Shortening
Ac-{d-Arg}-CEH-{d-Phe}-RWC-NH2 (Disulfide bridge: Cys2-Cys8)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 50 mg/mL (42.54 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8508 mL | 4.2541 mL | 8.5081 mL | 21.2703 mL |
| 5 mM | 0.1702 mL | 0.8508 mL | 1.7016 mL | 4.2541 mL | |
| 10 mM | 0.0851 mL | 0.4254 mL | 0.8508 mL | 2.1270 mL | |
| 15 mM | 0.0567 mL | 0.2836 mL | 0.5672 mL | 1.4180 mL | |
| 20 mM | 0.0425 mL | 0.2127 mL | 0.4254 mL | 1.0635 mL | |
| 25 mM | 0.0340 mL | 0.1702 mL | 0.3403 mL | 0.8508 mL | |
| 30 mM | 0.0284 mL | 0.1418 mL | 0.2836 mL | 0.7090 mL | |
| 40 mM | 0.0213 mL | 0.1064 mL | 0.2127 mL | 0.5318 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 Related Classifications
HY-P4764 Related Classifications
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