819048-44-7
819048-44-7
Chemical Structure
Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2
- CAS No.: 819048-44-7
- Formula:C51H70N18O11S2
- Molecular Weight:1175.35
InChIKey: UNXFCHHFXJFRRB-ZSTGMXRXSA-N
SMILES: O=C([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@H](NC(C)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45
Biological Activity: Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ac-(d-Arg)-CEH-(d-Phe)-RWC-NH2 | 99.96% | Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure. | ||||||||||||||||||||
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References
- [1]. Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065. [Content Brief]
Keywords
