581-05-5
Chemical Structure
α-MSH
Synonym(s): α-Melanocyte-Stimulating Hormone
- CAS. Nr.: 581-05-5
- Formula:C77H109N21O19S
- Molecular Weight:1664.88
IUPAC Name: (4S,7S,10S,13S,16S,22S)-7-((1H-imidazol-5-yl)methyl)-16-((1H-indol-3-yl)methyl)-26-amino-22-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carbonyl)-10-benzyl-13-(3-guanidinopropyl)-4-((2S,5S,8S,11S)-8-(4-hydroxybenzyl)-5,11-bis(hydroxymethyl)-2-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)-5,8,11,14,17,20-hexaoxo-6,9,12,15,18,21-hexaazahexacosanoic acid
InChIKey: WHNFPRLDDSXQCL-UAZQEYIDSA-N
SMILES: OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC(C)=O)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC2=CN=CN2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@H](C(N)=O)C(C)C)=O)=O)=O)=O)CC5=CNC6=CC=CC=C56)=O)=O)=O)=O)=O)=O)=O
Biological Activity: α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC)[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
α-MSH | 99.98% | α-MSH (α-Melanocyte-Stimulating Hormone), an endogenous neuropeptide, is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelanocortin (POMC). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Melanotan I | 99.93% | Melanotan I (MT-I; [Nle4,D-Phe7]-α-MSH) is an α-MSH (HY-P0252) analog, synthetic melanotropic peptide, and melanocortin receptor (MCR) agonist. Melanotan I induces skin tanning by mimicking the action of α-MSH on the melanocortin 1 receptor (MC1R) in melanocytes. As an appetite suppressant, Melanotan I impairs the ability of insulin to inhibit endogenous glucose production, suppresses leptin secretion from adipose tissue, and thereby reduces voluntary feed intake in ewes. Melanotan I can be used in research related to UV-induced skin damage, polymorphic light eruption, ruminant feeding, and sexual dysfunction. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
α-MSH free acid | α-MSH free acid (α-Melanocyte-Stimulating Hormone free acid) is an MC3R and MC4R agonist with EC50s of 0.16 nM and 5.6 nM, respectively. α-MSH free acid activates cAMP generation at MC3R and MC4R. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
SYSMEHFRWGKPS | SYSMEHFRWGKPS is a 13-amino acid peptide. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ACTH (1-13) | 99.31% | ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ACTH (1-14) | ACTH (1-14) is a fragment of adrenocorticotrophin, which regulates cortisol and androgen production. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
ACTH (1-16) (human) | 99.87% | ACTH (1-16) (human) (Adrenocorticotropic hormone (1-16)) is an ACTH fragment. ACTH (1-16) (human) improves cardiovascular function and survival in experimental hemorrhagic shock. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Nle4)-α-MSH | (Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(D-Phe7)-α-MSH | (D-Phe7)-α-MSH is an α-MSH analogue. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Des-acetyl)-α-MSH | (Des-acetyl)-α-MSH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Diacetyl)-α-MSH | (Diacetyl)-α-MSH is a peptide compound, which introduces an oxalyl (Diacetyl) group into the α-MSH molecule, which can increase the biological activity of the polypeptide. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Madhuri Singh, et al. C-terminal amino acids of alpha-melanocyte-stimulating hormone are requisite for its antibacterial activity against Staphylococcus aureus. Antimicrob Agents Chemother. 2011 May;55(5):1920-9. [Content Brief]
- [2]. M S Kim, et al. Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes. 2000 Feb;49(2):177-82. [Content Brief]
