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  3. Macelignan

Macelignan (Synonyms: (+)-Anwulignan; Anwuligan)

Cat. No.: HY-N0064 Purity: ≥98.0%
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Macelignan ((+)-Anwulignan; Anwuligan) is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities.

For research use only. We do not sell to patients.

Macelignan Chemical Structure

Macelignan Chemical Structure

CAS No. : 107534-93-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 306 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Macelignan ((+)-Anwulignan; Anwuligan) is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities[1][2][3].

IC50 & Target[1]

COX-2

 

In Vitro

Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm2, reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells[1].
Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Hacat cells
Concentration: 1 μM; 2.5 μM; 5 μM; 10 μM; 15 μM; 50 μM
Incubation Time: 72 hours
Result: Induced cell death by UVB irradiation at 30 mJ/cm2 from 10 μM.

Western Blot Analysis[1]

Cell Line: Hacat cells
Concentration: 0.1 μM; 0.5 μM;1 μM
Incubation Time: 24 hours
Result: Reduced UVB-induced COX-2 expression in cells.
In Vivo

Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ-db/db mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/KsJ-db/db mice[2]
Dosage: 15 mg/kg
Administration: Oral administration; 15 mg/kg; every day for three weeks
Result: Significantly reduced the blood glucose levels in mice.
Molecular Weight

328.40

Formula

C₂₀H₂₄O₄

CAS No.
SMILES

OC1=CC=C(C[[email protected]](C)[[email protected]](C)CC2=CC=C(OCO3)C3=C2)C=C1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (304.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0451 mL 15.2253 mL 30.4507 mL
5 mM 0.6090 mL 3.0451 mL 6.0901 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Macelignan(+)-Anwulignan AnwuliganCOXCyclooxygenaseanti-inflammatoryanti-canceranti-diabetesneuroprotectivelignanhacatInhibitorinhibitorinhibit

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