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Cat. No.: HY-161396

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Anti-inflammatory agent 76

Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, IL-1β and IL-6 inhibitory activities.

For research use only. We do not sell to patients.

Formula: C₂₆H₁₇FO₅
Molecular Weight:428.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Anti-inflammatory agent 76 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Anti-inflammatory agent 76 (Compd 8b), an anti-inflammatory agent, exhibits good NO, IL-1β and IL-6 inhibitory activities^[1].

All NO Synthase Isoforms :

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	0.66 μg/mL Compound: 8b	Antiinflammatory activity in LPS activated mouse RAW264.7 cells assessed as inhibition of NO production Antiinflammatory activity in LPS activated mouse RAW264.7 cells assessed as inhibition of NO production	[PMID: 38522589]
RAW264.7	IC₅₀	1.54 μM Compound: 8b	Antiinflammatory activity in LPS activated mouse RAW264.7 cells assessed as inhibition of NO production Antiinflammatory activity in LPS activated mouse RAW264.7 cells assessed as inhibition of NO production	[PMID: 38522589]

In Vitro

Anti-inflammatory agent 76 (Compd 8b) shows high potent NO inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with an IC₅₀ of 1.54 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 428.41
Formula C₂₆H₁₇FO₅
SMILES

COC(C=C1)=C(F)C=C1[C@H]2[C@H](C(C3=CC=CC=C3)=O)OC4=C2C(C5=CC=CC=C5C4=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ha Thanh Nguyen, et al. Improved synthesis, molecular modeling and anti-inflammatory activity of new fluorinated dihydrofurano-naphthoquinone compounds. Bioorg Med Chem Lett. 2024 Mar 22:104:129714. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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Anti-inflammatory agent 76

All NO Synthase Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anti-inflammatory agent 76 Related Classifications

HY-161396 Related Classifications