2. GPCR/G Protein Neuronal Signaling Autophagy Metabolic Enzyme/Protease Apoptosis
  3. Melatonin Receptor Autophagy Mitophagy Endogenous Metabolite Apoptosis
  4. Melatonin-d3

Melatonin-d3  (Synonyms: N-Acetyl-5-methoxytryptamine-d3)

Cat. No.: HY-B0075S1 Purity: 99.81%
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Melatonin-d3 is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

For research use only. We do not sell to patients.

Melatonin-d<sub>3</sub> Chemical Structure

Melatonin-d3 Chemical Structure

CAS No. : 90735-69-6

Size Price Stock Quantity
5 mg USD 240 In-stock
10 mg USD 380 In-stock
25 mg USD 760 In-stock
50 mg USD 1220 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Melatonin-d3:

Melatonin-d3 Related Antibodies

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Description

Melatonin-d3 is the deuterium labeled Melatonin. Melatonin is a hormone made by the pineal gland that can activates melatonin receptor. Melatonin plays a role in sleep and possesses important antioxidative and anti-inflammatory properties[1][2][3]. Melatonin is a novel selective ATF-6 inhibitor and induces human hepatoma cell apoptosis through COX-2 downregulation[4]. Melatonin attenuates palmitic acid-induced (HY-N0830) mouse granulosa cells apoptosis via endoplasmic reticulum stress[5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Melatonin-d3 Related Antibodies
Molecular Weight

235.30

Formula

C13H13D3N2O2
CAS No.
Appearance

Solid

Color

Pale purple to purple

SMILES

O=C(NCCC1=CNC2=C1C=C(OC)C=C2)C([2H])([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (424.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2499 mL 21.2495 mL 42.4989 mL
5 mM 0.8500 mL 4.2499 mL 8.4998 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2499 mL 21.2495 mL 42.4989 mL 106.2473 mL
5 mM 0.8500 mL 4.2499 mL 8.4998 mL 21.2495 mL
10 mM 0.4250 mL 2.1249 mL 4.2499 mL 10.6247 mL
15 mM 0.2833 mL 1.4166 mL 2.8333 mL 7.0832 mL
20 mM 0.2125 mL 1.0625 mL 2.1249 mL 5.3124 mL
25 mM 0.1700 mL 0.8500 mL 1.7000 mL 4.2499 mL
30 mM 0.1417 mL 0.7083 mL 1.4166 mL 3.5416 mL
40 mM 0.1062 mL 0.5312 mL 1.0625 mL 2.6562 mL
50 mM 0.0850 mL 0.4250 mL 0.8500 mL 2.1249 mL
60 mM 0.0708 mL 0.3542 mL 0.7083 mL 1.7708 mL
80 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3281 mL
100 mM 0.0425 mL 0.2125 mL 0.4250 mL 1.0625 mL
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Melatonin-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Melatonin-d390735-69-6N-Acetyl-5-methoxytryptamine-d3Melatonin ReceptorAutophagyMitophagyEndogenous MetaboliteApoptosisMitochondrial AutophagyInhibitorinhibitorinhibit

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