1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. COG 133 TFA

COG 133 TFA 

Cat. No.: HY-P1050A
Handling Instructions

COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC50 of 445 nM.

For research use only. We do not sell to patients.

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COG 133 TFA Chemical Structure

COG 133 TFA Chemical Structure

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Description

COG 133 TFA is a fragment of Apolipoprotein E (APOE) peptide. COG 133 TFA competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 TFA is also a nAChR antagonist with an IC50 of 445 nM[1][2].

IC50 & Target

IC50: 445 nM (nAChR)[2]

Molecular Weight

2283.78

Formula

C₉₉H₁₈₂F₃N₃₇O₂₁

Sequence

Ac-Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu-NH2

Sequence Shortening

Ac-LRVRLASHLRKLRKRLL-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

COG 133COG133COG-133nAChRNicotinic acetylcholine receptorsAPOEmimicsLDLanti-inflammatoryneuroprotectiveInhibitorinhibitorinhibit

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COG 133 TFA
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