2. Neuronal Signaling Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Amyloid-β PPAR HIF/HIF Prolyl-Hydroxylase
  4. Bavachinin

Bavachinin  (Synonyms: 7-O-Methylbavachin; Bavachinin A)

Cat. No.: HY-N0234 Purity: 99.95%
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SDS
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Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity..

For research use only. We do not sell to patients.

CAS No. : 19879-30-2

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10 mM * 1 mL in DMSO
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Bavachinin:

Bavachinin Related Antibodies

Top Publications Citing Use of Products

    Bavachinin purchased from MedChemExpress. Usage Cited in: Front Med. 2021 Aug;15(4):594-607.  [Abstract]

    Cytotoxicity in BMDMs treated with Bavachin (2.5, 5, 10, 20, 40, 60, 80, 120, and 160 µmol/L).

    Bavachinin purchased from MedChemExpress. Usage Cited in: Front Med. 2021 Aug;15(4):594-607.  [Abstract]

    LPS-primed BMDMs were treated with various doses of bavachin (2.5, 5, and 10 µmol/L) and then stimulated with ATP. Western blot analysis of IL-1β (p17) and caspase-1 (Casp-1 p20) in culture supernatants (Sup.) and pro-IL-1β, caspase-1 (Casp-1 p45), NLRP3, and ASC in cell lysates (Lys.).

    Bavachinin purchased from MedChemExpress. Usage Cited in: Front Med. 2021 Aug;15(4):594-607.  [Abstract]

    Immunofluorescence analysis in LPS-primed BMDMs treated with Bavachin (10 µmol/L) and then left stimulated with nigericin, followed by staining with Mitotracker red and DAPI.

    Bavachinin purchased from MedChemExpress. Usage Cited in: Front Med. 2021 Aug;15(4):594-607.  [Abstract]

    After staining and washing, flow cytometry was conducted to test mtROS production treated with Bavachin (5, 10 µmol/L).

    Bavachinin purchased from MedChemExpress. Usage Cited in: Front Med. 2021 Aug;15(4):594-607.  [Abstract]

    Female C57BL/6 mice were treated with LPS (2 mg/kg) or its saline vehicle through the tail vein. After 2 h, Bavachin (25 mg/kg) or its vehicle was administered through intraperitoneal injection. IL-1β and TNF-α were measured by ELISA.

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    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Bavachinin is agonist of pan-peroxisome proliferator-activated receptor (PPAR), with the IC50 value of 21.043 μM, 12.819 μM, and 0.622 μM to PPAR-α, RRAR-β/δ, and PPAR-γ, respectively. Bavachinin is an inhibitor of HIF-1α. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting RRAR-γ. Bavachinin is a natural compound with anti-inflammatory and anti-angiogenic activities. Bavachinin has orally bioactivity.[1][2][3][4][5].

    IC50 & Target

    PPAR-γ

    0.622 μM (IC50)

    PPARα

    21.043 μM (IC50)

    PPARδ

    12.819 μM (IC50)

    HIF-1α

     

    In Vitro

    Bavachinin (25，50 μM; 24 h) increases PPARγ protein expression[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Bavachinin Related Antibodies

    Immunofluorescence[4]

    Cell Line: A549 cells
    Concentration: 25 μM, 50 μM
    Incubation Time: 24 h
    Result: Showed PPARγ protein levels in both the cytoplasm and the nucleus were markedly higher.
    In Vivo

    Bavachinin (5 mg/kg; i.p.; four consecutive weeks) suppresses tumor growth and angiogenesis in Athymic nude mice bearing KB tumor[2].
    Bavachinin (50 mg/kg; p.o.; seven consecutive days) has therapeutic effect on asthma mice [3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Athymic nude mice inoculated subcutaneously KB cells[2]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection (i.p.)
    Result: Showed significantly reduced the tumor volume by 40.06%, and had fewer vessels of luminal size.
    Animal Model: Asthma mice[3]
    Dosage: 50 mg/kg
    Administration: Oral gavage (p.o.)
    Result: Showed significantly inhibiting the serum levels of both IL-4 and IgE.
    Molecular Weight

    338.40

    Formula

    C21H22O4
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(OC)=C(C/C=C(C)\C)C=C13
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 125 mg/mL (369.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL
    5 mM 0.5910 mL 2.9551 mL 5.9102 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Volume
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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

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    C2

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    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.95%

    SDS (393 KB)

    COA (246 KB) HNMR (141 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9551 mL 14.7754 mL 29.5508 mL 73.8771 mL
    5 mM 0.5910 mL 2.9551 mL 5.9102 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 7.3877 mL
    15 mM 0.1970 mL 0.9850 mL 1.9701 mL 4.9251 mL
    20 mM 0.1478 mL 0.7388 mL 1.4775 mL 3.6939 mL
    25 mM 0.1182 mL 0.5910 mL 1.1820 mL 2.9551 mL
    30 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4626 mL
    40 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
    50 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
    60 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2313 mL
    80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7388 mL
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    Bavachinin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Bavachinin19879-30-27-O-Methylbavachin Bavachinin AAmyloid-βPPARHIF/HIF Prolyl-Hydroxylaseβ-amyloid peptideAβAbetaPeroxisome proliferator-activated receptorsHypoxia-inducible factorsHIFsHIF-PHPPAR AgonistHIF-1α InhibitorCancerAnti-inflammationInhibitorinhibitorinhibit

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