Sanggenon A
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide.
For research use only. We do not sell to patients.
- CAS No.: 76464-71-6
- Formula: C25H24O7
- Molecular Weight:436.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
NF-κB |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HSC-2 | CC50 |
53 μM
Compound: 17
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Cytotoxicity against human HSC2 cells
Cytotoxicity against human HSC2 cells
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[PMID: 11429996] |
Chemical Information
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CAS No. 76464-71-6
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Molecular Weight 436.45
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Formula C25H24O7
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SMILES
C/C(C)=C\C[C@@]12[C@@](C(C3=C(O)C(C=CC(C)(O4)C)=C4C=C3O1)=O)(OC5=CC(O)=CC=C52)O
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Synonyms
Sanggenone A
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sanggenon A Related Classifications
HY-N11657 Related Classifications
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