1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. sPLA2 inhibitor 1

sPLA2 inhibitor 1 

Cat. No.: HY-11059
Handling Instructions

sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity.

For research use only. We do not sell to patients.

sPLA2 inhibitor 1 Chemical Structure

sPLA2 inhibitor 1 Chemical Structure

CAS No. : 393569-31-8

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Description

sPLA2 inhibitor 1, a D-tyrosine derivative, is an orally active, potent secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 29 nM for human nonpancreatic secretory PLA2 isoform IIa (hnpsPLA2-IIa). sPLA2 inhibitor 1 has anti-inflammatory activity[1].

IC50 & Target[1]

sPLA2

29 nM (IC50)

In Vivo

sPLA2 inhibitor 1 (compound 2b; oral; 5 mg/kg/day; on Days 10-13 after inoculation with arthritogen) shows substantial inhibition of the oedema. Drug-treated rats shows mild capsular oedema and minimal infiltration of macrophages into the red pulp[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

487.63

Formula

C₃₁H₃₇NO₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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sPLA2 inhibitor 1
Cat. No.:
HY-11059
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