GW1929 hydrochloride
Based on 12 publication(s) in Google Scholar
GW1929 hydrochloride is an orally active peroxisome proliferator-activated receptor-γ (PPARγ) agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively. GW1929 hydrochloride has antidiabetic efficacy and neuroprotective potential. GW1929 hydrochloride suppresses neuronal apoptosis and shows anti-inflammatory potential.
For research use only. We do not sell to patients.
- CAS No.: 1217466-21-1
- Formula: C30H30ClN3O4
- Molecular Weight:532.03
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) GW1929 hydrochloride
More- Nat Commun. 2025 Aug 27;16(1):8009. [Abstract]
- Cell Death Dis. 2024 Aug 26;15(8):623. [Abstract]
- Mater Today Bio. 2026 Feb 4:37:102865. [Abstract]
- Phytother Res. 2023 Nov;37(11):5394-5406. [Abstract]
- J Agric Food Chem. 2024 Jun 5;72(22):12541-12554. [Abstract]
- Ecotoxicol Environ Saf. 2020 Sep 15:201:110801. [Abstract]
- Food Biosci. 2026 Apr 18;80:108920.
- J Zhejiang Univ Sci B. 2020;21(12):990-998. [Abstract]
- Int Immunopharmacol. 2023 Sep 9;124(Pt A):110840. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3322-3338. [Abstract]
- J Cell Mol Med. 2025 May;29(9):e70416. [Abstract]
- Aging (Albany NY). 2021 May 25;13(11):15240-15254. [Abstract]
Customer Validation & Images
-
In Vivo Efficacy Study
-
IF
-
WB
-
WB
Biological Activity
|
hPPARγ 8.84 (pKi) |
GW1929 hydrochloride is a potent PPAR-γ activator, with pKis of 8.84, < 5.5, and < 6.5 for human PPAR-γ, PPAR-α, and PPAR-δ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively[1].
GW1929 hydrochloride (10 μM) inhibits TBBPA-induced caspase-3 increase and TBBPA-stimulated LDH release in neocortical cell cultures[2].
GW1929 hydrochloride shows significant reduction in the COX-2, iNOS, MMP-9, TNFα and IL-6 levels[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
GW1929 hydrochloride (1, 5 mg/kg, p.o.) increases glucose-stimulated insuline secretion of β-cell in ZDF rats[1]. GW1929 hydrochloride (10 mg/kg body weight) results in amelioration of muscle loss in tumour-bearing mice experimental cachexia[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1217466-21-1
-
Molecular Weight 532.03
-
Formula C30H30ClN3O4
-
SMILES
O=C(C1=CC=CC=C1)C2=C(C=CC=C2)N[C@H](C(O)=O)CC3=CC=C(C=C3)OCCN(C4=CC=CC=N4)C.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (12)
-
Journal Impact Factor
-
Most Recent
-
Nat Commun
Remodeling adipocytes' lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow. [Abstract]2025 Aug 27;16(1):8009. PMID: 40866384 -
Cell Death Dis
TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36. [Abstract]2024 Aug 26;15(8):623. PMID: 39187498
GW1929 hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2024 Aug 26;15(8):623. [Abstract]
Quantitative analysis of the outer nuclear layer thickness in SSO (sulfosuccinimidyl oleate) (50 mg/kg, oral gavage)-treated MNU-induced WT mouse retina and GW1929 (30 mg/kg, intraperitoneal injection, twice)+SSO treated MNU-induced Trem2−/− mouse retina.
-
Mater Today Bio
Intelligent nanoliposome ameliorate chronic intermittent hypoxia-mediated neuronal injury via a dual regulation microglial inflammation strategy. [Abstract]2026 Feb 4:37:102865. PMID: 41716351 -
Phytother Res
Angelica sinensis polysaccharide improves mitochondrial metabolism of osteoarthritis chondrocytes through PPARγ/SOD2/ROS pathways. [Abstract]2023 Nov;37(11):5394-5406. PMID: 37632225 -
J Agric Food Chem
Walnut-Derived Peptides Ameliorate Scopolamine-Induced Memory Impairments in a Mouse Model via Activation of Peroxisome Proliferator-Activated Receptor γ-Mediated Excitotoxicity. [Abstract]2024 Jun 5;72(22):12541-12554. PMID: 38785039 -
Ecotoxicol Environ Saf
Inflammasome/NF-κB translocation inhibition via PPARγ agonist mitigates inorganic mercury induced nephrotoxicity. [Abstract]2020 Sep 15:201:110801. PMID: 32502906
GW1929 hydrochloride purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2020 Sep 15:201:110801. [Abstract]
PPARγ agonist (GW 1929) effectively increased the PPARγ expression. Immunofluorescence staining analysis the expression levels of PPARγ in HK2 cells.
GW1929 hydrochloride purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2020 Sep 15:201:110801. [Abstract]
PPARγ agonist (GW 1929) effectively increased the PPARγ expression. Western blotting analysis the expression levels of PPARγ in HK2 cells.
-
-
J Zhejiang Univ Sci B
Silencing of DsbA-L gene impairs the PPARγ agonist function of improving insulin resistance in a high-glucose cell model. [Abstract]2020;21(12):990-998. PMID: 33843164 -
Int Immunopharmacol
CTRP6 regulates M1 macrophage polarization via the PPAR-γ/NF-κB pathway and reprogramming glycolysis in recurrent spontaneous abortion. [Abstract]2023 Sep 9;124(Pt A):110840. PMID: 37696144 -
Biochim Biophys Acta Mol Basis Dis
LAZ3 protects cardiac remodeling in diabetic cardiomyopathy via regulating miR-21/PPARa signaling. [Abstract]2018 Oct;1864(10):3322-3338. PMID: 30031228
GW1929 hydrochloride purchased from MedChemExpress. Usage Cited in: Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3322-3338. [Abstract]
LAZ3 knock-down decreases NRF2 expression and nuclear translocation, while only the PPARa agonist (GW7647) can prevent this inhibition. Both PPARγ agonist (GW1929) and PPARδ agonist (GW0742) can not reverse these inhibitions.
-
J Cell Mol Med
Disruption of PPARG Activity and CPT1A Regulation by Bisphenol A: Implications for Hepatic Lipid Metabolism. [Abstract]2025 May;29(9):e70416. PMID: 40346756 -
Aging (Albany NY)
Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation. [Abstract]2021 May 25;13(11):15240-15254. PMID: 34035184
Purity & Documentation
References
[1]. Brown KK, et al. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes. 1999 Jul;48(7):1415-24. [Content Brief]
[2]. Wojtowicz AK, et al. PPAR-γ agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells. Neurotox Res. 2014 Apr;25(3):311-22. [Content Brief]
[3]. Kaundal RK, et al. Ameliorative effects of GW1929, a nonthiazolidinedione PPARγ agonist, on inflammation and apoptosis in focal cerebral ischemic-reperfusion injury. Curr Neurovasc Res. 2011 Aug 1;8(3):236-45. [Content Brief]
[4]. Moore-Carrasco R, et al. Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing mice. Oncol Rep. 2008 Jan;19(1):253-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GW1929 hydrochloride Related Classifications
HY-110022 Related Classifications
Powered by Bioz