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Rimexolone (Synonyms: Org 6216; Rimexel)

Cat. No.: HY-B1754
Handling Instructions

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation.

For research use only. We do not sell to patients.

Rimexolone Chemical Structure

Rimexolone Chemical Structure

CAS No. : 49697-38-3

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Description

Rimexolone (Org 6216) is a glucocorticoid steroid with anti-inflammatory activity. Rimexolone can be used as a 1% ophthalmic suspension for the management of ocular inflammation[1][2].

In Vitro

Rimexolone (Org 6216) shows highly enhanced persistence at the injection site, minimal systematic effects and virtually does not induce skin artrophy[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Rimexolone (Org 6216) (0-450 μg/mouse; intraarticular injection; once) shows prolonged anti-inflammatory action in mice with monoarticular antigen-induced arthritis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male, 8-12 weeks old C57Black/6 mice with antigen induced arthritis[1]
Dosage: 5, 25, 50, 150, 250, 450 μg/mouse
Administration: Intraarticular injection, once
Result: Suppressed the arthritis in a dose-dependent manner.
Significantly prevented osteophyte formation at 450 and 150 μg.
Resulted in a decrease of the inhibition of the chondrocyte proteoglycan synthesis.
Molecular Weight

370.52

Formula

C24H34O3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Rimexolone
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