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Cat. No.: HY-P1098B

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Ac2-26 ammonium

8 Cited Publications

Customer Review

Based on 8 publication(s) in Google Scholar

Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model.

For research use only. We do not sell to patients.

Purity: 97.45%
Formula: C₁₄₁H₂₁₀N₃₂O₄₄S.xNH₃
Molecular Weight:3089.43 (free base)

Storage:

Sealed storage, away from moisture and light, under nitrogen.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Ac2-26 ammonium Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All IKK Isoforms :

In Vitro

Ac2-26 (0.5 μM, 24 h) inhibits the production of infammatory cytokines and apoptosis in LPS-induced HK-2 cells^[5]. Ac2-26 (1 μM, 48 h) increases rat cardiomyocyte expression of rFprs and prevents cell injury^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ac2-26 (1 mg/kg/d, i.v. since reperfusion until day 7) reduces cardiac necrosis and cardiac inflammation in mice 24 h/48 h post I-R injury model^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 3089.43 (free base)
Formula C₁₄₁H₂₁₀N₃₂O₄₄S.xNH₃
Color White to off-white
Sequence

Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys
Sequence Shortening

Ac-AMVSEFLKQAWFIENEEQEYVQTVK
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Publications (8)

All WBRT-PCRCell Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Signal Transduct Target Ther

Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity. [Abstract]

2024 Aug 23;9(1):218. PMID: 39174522

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.
Cancer Cell

Epithelial cells activate fibroblasts to promote esophageal cancer development. [Abstract]

2023 May 8;41(5):903-918.e8. PMID: 36963399

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]

Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.
Nat Nanotechnol

Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]

2025 Aug 11. PMID: 40789923
Mater Today Bio

Peptide loaded self-healing hydrogel promotes diabetic skin wound healing through macrophage orchestration and inflammation inhibition. [Abstract]

2025 Mar 20:32:101690. PMID: 40225136
World J Gastroenterol

Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway. [Abstract]

2023 Jun 14;29(22):3422-3439. PMID: 37389234
iScience

Annexin A1 exerts analgesic effect in a mouse model of medication overuse headache. [Abstract]

2023 Oct 6;26(11):108153. PMID: 37867938
Exp Cell Res

ANXA1 inhibits ferroptosis in HUVECs via negative regulation of ferritinophagy. [Abstract]

2026 Jan 1;454(1):114825. PMID: 41241173
Biol Reprod

ANXA1 inhibits trophoblast ferroptosis in preeclampsia by downregulating KISS1†. [Abstract]

2025 Mar 26:ioaf060. PMID: 40143407

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (ultrasonic and adjust pH to 8 with NH3·H2O)

View the Complete Stock Solution Preparation Table

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang LM, et al. Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D₂. Int Arch Allergy Immunol. 2011;154(2):137-48. [Content Brief]

[2]. Gong J, et al. Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway. Biomed Pharmacother. 2019 Sep;117:109194. [Content Brief]

[3]. Luo Z, et al. Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain. Cell Mol Neurobiol. 2020 May;40(4):569-585. [Content Brief]

[4]. Liu L, et al. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Front Mol Neurosci. 2018 Mar 15;11:76. [Content Brief]

[5]. Zheng Y, et al. Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. Inflamm Res. 2023 Feb;72(2):347-362. [Content Brief]

[6]. Qin CX, et al. Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction. Front Pharmacol. 2019 Apr 3;10:269. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Ac2-26 ammonium

8 Cited Publications

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (8)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

1/16
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]

Customer Validation
Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.

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Ac2-26 ammonium

Peptide Library

Publications Citing Use of MedChemExpress (MCE) Ac2-26 ammonium

All IKK Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Purity & Documentation

References

Calculators

Help & FAQs

Ac2-26 ammonium

Peptide Library

Publications Citing Use of MedChemExpress (MCE) Ac2-26 ammonium

All IKK Isoforms

Biological Activity

Chemical Information

Publications (8)

Solvent & Solubility

Purity & Documentation

References

Calculators

Help & FAQs

Ac2-26 ammonium Related Classifications

HY-P1098B Related Classifications