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製品番号: HY-P1098B

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Ac2-26 ammonium

Name: Ac2-26 ammonium
Brand: MedChemExpress
SKU: HY-P1098B
Price: 150.00 USD
Availability: InStock
Rating: 5 (9 reviews)

9 Cited Publications

カスタマーレビュー

Based on 9 publication(s) in Google Scholar

Ac2-26 ammonium is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 ammonium induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ammonium ameliorates lung ischemia-reperfusion injury. Ac2-26 ammonium also inhibits airway inflammation and hyperresponsiveness in an asthma rat model.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 97.45%
分子式: C₁₄₁H₂₁₀N₃₂O₄₄S.xNH₃
分子量:3089.43 (free base)

保管条件:

Sealed storage, away from moisture and light, under nitrogen.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Ac2-26 ammonium 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IKK アイソフォーム固有の製品をすべて表示 :

体外実験

Ac2-26 (0.5 μM, 24 h) inhibits the production of infammatory cytokines and apoptosis in LPS-induced HK-2 cells^[5]. Ac2-26 (1 μM, 48 h) increases rat cardiomyocyte expression of rFprs and prevents cell injury^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Ac2-26 (1 mg/kg/d, i.v. since reperfusion until day 7) reduces cardiac necrosis and cardiac inflammation in mice 24 h/48 h post I-R injury model^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

性状 Solid
分子量 3089.43 (free base)
分子式 C₁₄₁H₂₁₀N₃₂O₄₄S.xNH₃
Color White to off-white
配列

Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys
シーケンスの短縮

Ac-AMVSEFLKQAWFIENEEQEYVQTVK
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Publications (9)

All WBRT-PCRCell Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Signal Transduct Target Ther

Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity. [Abstract]

2024 Aug 23;9(1):218. PMID: 39174522

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.
Cancer Cell

Epithelial cells activate fibroblasts to promote esophageal cancer development. [Abstract]

2023 May 8;41(5):903-918.e8. PMID: 36963399

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]

Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.
Nat Nanotechnol

Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]

2025 Aug 11. PMID: 40789923
Mater Today Bio

Peptide loaded self-healing hydrogel promotes diabetic skin wound healing through macrophage orchestration and inflammation inhibition. [Abstract]

2025 Mar 20:32:101690. PMID: 40225136
World J Gastroenterol

Mechanism of annexin A1/N-formylpeptide receptor regulation of macrophage function to inhibit hepatic stellate cell activation through Wnt/β-catenin pathway. [Abstract]

2023 Jun 14;29(22):3422-3439. PMID: 37389234
iScience

Annexin A1 exerts analgesic effect in a mouse model of medication overuse headache. [Abstract]

2023 Oct 6;26(11):108153. PMID: 37867938
Exp Cell Res

ANXA1 inhibits ferroptosis in HUVECs via negative regulation of ferritinophagy. [Abstract]

2026 Jan 1;454(1):114825. PMID: 41241173
Biol Reprod

ANXA1 inhibits trophoblast ferroptosis in preeclampsia by downregulating KISS1†. [Abstract]

2025 Jun 15;112(6):1256-1272. PMID: 40143407
Exp Eye Res

Annexin A1-Fpr2/ALX signaling in Candida keratitis: Regulatory role in pathogenesis and resolution. [Abstract]

2026 Jul 21:271:111181. PMID: 42480956

溶剤 & 溶解度

体外:

H₂O : 50 mg/mL (ultrasonic and adjust pH to 8 with NH3·H2O)

View the Complete Stock Solution Preparation Table

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Wang LM, et al. Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D₂. Int Arch Allergy Immunol. 2011;154(2):137-48. [Content Brief]

[2]. Gong J, et al. Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway. Biomed Pharmacother. 2019 Sep;117:109194. [Content Brief]

[3]. Luo Z, et al. Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain. Cell Mol Neurobiol. 2020 May;40(4):569-585. [Content Brief]

[4]. Liu L, et al. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Front Mol Neurosci. 2018 Mar 15;11:76. [Content Brief]

[5]. Zheng Y, et al. Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. Inflamm Res. 2023 Feb;72(2):347-362. [Content Brief]

[6]. Qin CX, et al. Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction. Front Pharmacol. 2019 Apr 3;10:269. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Ac2-26 ammonium

9 Cited Publications

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Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]

Customer Validation
Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.
1/16

Ac2-26 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]

Customer Validation
Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.

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Ac2-26 ammonium

MedChemExpress（MCE）の使用を引用している文献 Ac2-26 ammonium

IKK アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

Publications (9)

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Bioz

Keywords

最近チェックした製品

Ac2-26 ammonium

MedChemExpress（MCE）の使用を引用している文献 Ac2-26 ammonium

IKK アイソフォーム固有の製品をすべて表示

生物活性

製品説明

体外実験

体内実験

化学情報

Publications (9)

溶剤 & 溶解度

体外:

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Ac2-26 ammonium 関連分類

HY-P1098B 関連分類

Bioz

Keywords

最近チェックした製品