2. Cytoskeleton NF-κB
  3. Annexin A NF-κB
  4. Ac2-26

Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model.

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Custom Peptide Synthesis

CAS No. : 151988-33-9

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Ac2-26:

Ac2-26 Related Antibodies

Top Publications Citing Use of Products

    Ac2-26 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218.  [Abstract]

    Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.

    Ac2-26 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218.  [Abstract]

    Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.

    Ac2-26 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218.  [Abstract]

    Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.

    Ac2-26 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218.  [Abstract]

    Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.

    Ac2-26 purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8.  [Abstract]

    Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.

    View All Annexin A Isoform Specific Products:

    View All Isoforms
    AnxA1 AnxA3 AnxA4 AnxA6 AnxA7 AnxA8 AnxA9 AnxA10 AnxA11 AnxA13

    View All NF-κB Isoform Specific Products:

    View All Isoforms
    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model[1][2][3][4].

    In Vitro

    Ac2-26 (0.5 μM, 24 h) inhibits the production of infammatory cytokines and apoptosis in LPS-induced HK-2 cells[5]. Ac2-26 (1 μM, 48 h) increases rat cardiomyocyte expression of rFprs and prevents cell injury[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ac2-26 Related Antibodies
    In Vivo

    Ac2-26 (1 mg/kg/d, i.v. since reperfusion until day 7) reduces cardiac necrosis and cardiac inflammation in mice 24 h/48 h post I-R injury model[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    3089.43

    Formula

    C141H210N32O44S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys
    Sequence Shortening

    Ac-AMVSEFLKQAWFIENEEQEYVQTVK
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (6.47 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 7.14 mg/mL (2.31 mM; adjust pH to 10 with NaOH)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.3237 mL 1.6184 mL 3.2368 mL
    5 mM 0.0647 mL 0.3237 mL 0.6474 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: ≥ 3.33 mg/mL (1.08 mM); Clear solution

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.43%

    SDS (252 KB)

    COA (254 KB) RP-HPLC (254 KB) MS (68 KB) Elemental Analysis Report (112 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 0.3237 mL 1.6184 mL 3.2368 mL 8.0921 mL
    DMSO 5 mM 0.0647 mL 0.3237 mL 0.6474 mL 1.6184 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Ac2-26 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ac2-26151988-33-9Annexin ANF-κBAnxANuclear factor-κBNuclear factor-kappaBLPSanti-inflammatoryannexin 1airway inflammationhyperresponsivenessasthmaInhibitorinhibitorinhibit

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