Ac2-26 TFA

Name: Ac2-26 TFA
Brand: MedChemExpress
SKU: HY-P1098A
Rating: 5.0 (8 reviews)

Cat. No.: HY-P1098A Purity: 98.09%: Data Sheet
COA

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Ac2-26 TFA is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Ac2-26 TFA:

Ac2-26 In-stock
Ac2-26 ammonium In-stock

8 Publications Citing Use of MCE Ac2-26 TFA

RT-PCR

Cell Imaging/Staining

In Vivo Efficacy Study

: Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]; Ac2-26 (0.1 mg/mL; 48 h) significantly reduced SMAD4 protein levels in SVFs.

: Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]; Ac2-26 (0.1 mg/mL; 48 h) significantly decreased mRNA levels of key genes in adipogenesis of SVFs.

: Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]; Ac2-26 (0.1 mg/mL; 48 h) significantly reduced the induced differentiation potential of SVFs.

: Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Aug 23;9(1):218. [Abstract]; Ac2-26 (2 mg/kg; i.p.; every other day for 10 weeks) significantly decreased the blood glucose, TC, and TG levels in 8-week-old db/db mice fed with HFD.

: Ac2-26 TFA purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 May 8;41(5):903-918.e8. [Abstract]; Ac2-26 (100 mg; i.p.; 3 times a week for 5 weeks) significantly reduced the tumor burdens in ESCC (esophageal squamous-cell carcinoma) mice induced by the carcinogen 4-NQO.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Ac2-26 (0.5 μM, 24 h) inhibits the production of infammatory cytokines and apoptosis in LPS-induced HK-2 cells^[5]. Ac2-26 (1 μM, 48 h) increases rat cardiomyocyte expression of rFprs and prevents cell injury^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ac2-26 (1 mg/kg/d, i.v. since reperfusion until day 7) reduces cardiac necrosis and cardiac inflammation in mice 24 h/48 h post I-R injury model^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3203.45 (free base)

Formula

C₁₄₃H₂₁₁F₃N₃₂O₄₆S.xC₂HF₃O₂

Appearance

Solid

Color

White to off-white

Sequence

Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys

Sequence Shortening

Ac-AMVSEFLKQAWFIENEEQEYVQTVK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 33.33 mg/mL (adjust pH to 9 with NH3·H2O)

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 1 mg/mL; Clear solution; Need ultrasonic and adjust pH to 9 with NaOH

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.09%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (255 KB) RP-HPLC (201 KB) MS (106 KB)

Handling Instructions (2659 KB)

References

[1]. Wang LM, et al. Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D₂. Int Arch Allergy Immunol. 2011;154(2):137-48. [Content Brief]

[2]. Liu L, et al. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Front Mol Neurosci. 2018 Mar 15;11:76. [Content Brief]

[3]. Gong J, et al. Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway. Biomed Pharmacother. 2019 Sep;117:109194. [Content Brief]

[4]. Luo Z, et al. Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain. Cell Mol Neurobiol. 2020 May;40(4):569-585. [Content Brief]

[5]. Zheng Y, et al. Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. Inflamm Res. 2023 Feb;72(2):347-362. [Content Brief]

[6]. Qin CX, et al. Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction. Front Pharmacol. 2019 Apr 3;10:269. [Content Brief]

Ac2-26 TFA Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac2-26Annexin ANF-κBAnxANuclear factor-κBNuclear factor-kappaBLPSanti-inflammatoryannexin 1airway inflammationhyperresponsivenessasthmaInhibitorinhibitorinhibit

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Ac2-26 TFA

Customer Review

Other Forms of Ac2-26 TFA:

Ac2-26 TFA Related Antibodies

8 Publications Citing Use of MCE Ac2-26 TFA

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Annexin A Isoform Specific Products:

View All NF-κB Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Ac2-26 TFA Related Antibodies

Molarity Calculator

Dilution Calculator

Ac2-26 TFA Related Classifications

Keywords:

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Customer Review

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