BODIPY 581/591 C11
Based on 155 publication(s) in Google Scholar
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type).
For research use only. We do not sell to patients.
- Purity: 99.08%
- CAS No.: 217075-36-0
- Formula: C30H35BF2N2O2
- Molecular Weight:504.42
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications Citing Use of MedChemExpress (MCE) BODIPY 581/591 C11
More- Signal Transduct Target Ther. 2025 Dec 3;10(1):394. [Abstract]
- Signal Transduct Target Ther. 2023 Aug 16;8(1):302. [Abstract]
- Adv Mater. 2025 Jan;37(3):e2409176. [Abstract]
- Adv Mater. 2023 Nov;35(48):e2306469. [Abstract]
- Cell Host Microbe. 2026 Jan 14;34(1):35-51.e9. [Abstract]
- Drug Resist Updat. 2023 May:68:100936. [Abstract]
- Sci Bull. 2023 Jan 15;68(1):77-94. [Abstract]
- Nat Commun. 2025 Dec 13. [Abstract]
- Nat Commun. 2025 Jul 1;16(1):5491. [Abstract]
- ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]
- ACS Nano. 2023 Feb 28;17(4):3518-3527. [Abstract]
- Redox Biol. 2026 Jun 21:95:104271. [Abstract]
- Gut Microbes. 2025 Dec;17(1):2489072. [Abstract]
- J Nanobiotechnology. 2025 Jun 2;23(1):409. [Abstract]
- J Nanobiotechnology. 2024 Jul 20;22(1):430. [Abstract]
- Acta Pharm Sin B. 2025 Dec;15(12):6461-6477. [Abstract]
- J Exp Clin Cancer Res. 2025 Dec 24;44(1):323. [Abstract]
- J Exp Clin Cancer Res. 2025 Dec 29;44(1):329. [Abstract]
- J Exp Clin Cancer Res. 2025 Sep 30;44(1):272. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(22):e21997. [Abstract]
- Adv Sci (Weinh). 2025 Sep;12(34):e05070. [Abstract]
- Adv Sci (Weinh). 2025 Aug;12(30):e01042. [Abstract]
- MedComm (2020). 2024 Jun 5;5(6):e571. [Abstract]
- Adv Sci (Weinh). 2023 Oct;10(30):e2303872. [Abstract]
- Sci Adv. 2026 May;12(18):eaee4401. [Abstract]
- Chem Eng J. 2025 Sep 19;523:168705.
- Chem Eng J. 2025 Aug 1.
- Chem Eng J. 2025 Jun 15.
- Chem Eng J. 2024 Nov 15.
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- J Control Release. 2024 Sep 18:375:422-437. [Abstract]
- Cell Death Dis. 2025 Apr 7;16(1):261. [Abstract]
- Cell Death Dis. 2025 Feb 3;16(1):64. [Abstract]
- Small. 2023 Mar;19(10):e2206415. [Abstract]
- NPJ Biofilms Microbiomes. 2025 Jun 21;11(1):113. [Abstract]
- Phytomedicine. 2025 Jul 25:143:156911. [Abstract]
- EBioMedicine. 2025 Dec 8;123:106058.
- Mater Today Bio. 2026 May 6:38:103208. [Abstract]
- Mater Today Bio. 2026 Feb 23:37:102965. [Abstract]
- J Hazard Mater. 2025 Jul 15:492:137969. [Abstract]
- J Hazard Mater. 2025 Mar 15:486:137037. [Abstract]
- Cell Death Discov. 2025 Apr 9;11(1):160. [Abstract]
- J Transl Med. 2025 Jan 8;23(1):30. [Abstract]
- J Colloid Interface Sci. 2025 Sep:693:137611. [Abstract]
- Basic Res Cardiol. 2025 Jun 15. [Abstract]
- Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]
- Apoptosis. 2026 May 24;31(6):150. [Abstract]
- Int J Biol Macromol. 2026 May:361:151921. [Abstract]
- Int J Biol Macromol. 2025 Dec 30;339(Pt 2):149976. [Abstract]
- Int J Biol Macromol. 2025 Dec 4;337(Pt 1):149424. [Abstract]
- Int J Nanomedicine. 2025 Mar 10:20:2901-2921. [Abstract]
- Mol Med. 2024 Nov 15;30(1):219. [Abstract]
- Free Radic Biol Med. 2025 Nov 23:243:398-413. [Abstract]
- Free Radic Biol Med. 2025 Aug 1:235:231-247. [Abstract]
- Free Radic Biol Med. 2025 Aug 19:240:170-182. [Abstract]
- ACS Appl Mater Interfaces. 2025 Aug 6;17(31):44922-44938. [Abstract]
- J Med Chem. 2024 Feb 22;67(4):2758-2776. [Abstract]
- Genomics Proteomics Bioinformatics. 2025 Dec 23:qzaf131. [Abstract]
- Cancer Cell Int. 2024 Jun 5;24(1):200. [Abstract]
- Pharmaceutics. 2024 Sep 13;16(9):1205. [Abstract]
- J Ethnopharmacol. 2026 May 23:363:121445. [Abstract]
- Virulence. 2025 Dec;16(1):2543981. [Abstract]
- Neurosci Bull. 2025 May 29. [Abstract]
- J Ethnopharmacol. 2024 Nov 15:334:118582. [Abstract]
- J Agric Food Chem. 2025 Jul 30;73(30):18804-18821. [Abstract]
- Eur J Med Chem. 2023 Dec 5:261:115829. [Abstract]
- Ecotoxicol Environ Saf. 2026 Jun 8:322:120347. [Abstract]
- Ecotoxicol Environ Saf. 2026 May:316:120144. [Abstract]
- Ecotoxicol Environ Saf. 2023 Sep 15:263:115279. [Abstract]
- Biochem Pharmacol. 2026 Jan;243(Pt 1):117519. [Abstract]
- Biochem Pharmacol. 2026 Jan;243(Pt 2):117522. [Abstract]
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- Biochem Pharmacol. 2025 Aug 15;242(Pt 1):117243. [Abstract]
- Biochem Pharmacol. 2025 Mar:233:116790. [Abstract]
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- Life Sci. 2024 Aug 15:351:122848. [Abstract]
- Life Sci. 2024 Aug 15:351:122780. [Abstract]
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- Transl Res. 2026 Jun:292:26-39. [Abstract]
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- Oncogenesis. 2025 Nov 21;14(1):45. [Abstract]
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- ACS Appl Bio Mater. 2026 May 4;9(9):4297-4313. [Abstract]
- Int Immunopharmacol. 2025 Oct 10:163:115268. [Abstract]
- Int Immunopharmacol. 2025 Apr 16:152:114400. [Abstract]
- Biol Direct. 2026 Apr 27;21(1):96. [Abstract]
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- Arab J Chem. 2025 Nov 14.
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- Microchem J. 2026 Jan 6;221:116823.
- Chem Biol Interact. 2026 Jan 5:423:111838. [Abstract]
- Food Sci Nutr. 2026 Mar 10;14(3):e71495. [Abstract]
- Food Sci Nutr. 2025 Dec 21;13(12):e71341. [Abstract]
- Mol Med Rep. 2025 Mar;31(3):60. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Oct;1870(7):167435. [Abstract]
- Sci Rep. 2026 Feb 28. [Abstract]
- Sci Rep. 2024 Jul 27;14(1):17318. [Abstract]
- Cancers (Basel). 2023 Apr 23;15(9):2427. [Abstract]
- J Cell Mol Med. 2026 Apr;30(8):e71147. [Abstract]
- Cell Signal. 2026 Feb:138:112256. [Abstract]
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- J Cell Mol Med. 2024 Dec;28(23):e70278. [Abstract]
- J Inflamm Res. 2026 Jun 19:19:596461. [Abstract]
- J Inflamm Res. 2024 Nov 15:17:8861-8879. [Abstract]
- Brain Res Bull. 2025 Sep:229:111434. [Abstract]
- iScience. 2025 Jul 25;28(8):113097. [Abstract]
- iScience. 2024 Mar 14;27(4):109504. [Abstract]
- Fish Shellfish Immunol. 2025 Oct 8:168:110908. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Dec 18. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar 8. [Abstract]
- J Funct Foods. 2025 Apr.
- Skelet Muscle. 2024 Dec 3;14(1):29. [Abstract]
- Toxicol Appl Pharmacol. 2024 Dec:493:117148. [Abstract]
- Appl Biochem Biotechnol. 2026 Jan 8. [Abstract]
- Photochem Photobiol Sci. 2025 Mar;24(3):499-509. [Abstract]
- Int J Biochem Cell Biol. 2024 Dec:177:106691. [Abstract]
- Mol Cell Endocrinol. 2026 Mar:613:112721. [Abstract]
- Atheroscler Plus. 2025 Jun 6:61:1-11. [Abstract]
- J Neurooncol. 2025 Apr;172(2):377-386. [Abstract]
- Cardiovasc Toxicol. 2025 Aug;25(8):1169-1180. [Abstract]
- Adv Biol (Weinh). 2025 Aug;9(8):e2400648. [Abstract]
- J Immunol Res. 2023 Jun 30:2023:2061071. [Abstract]
- Hum Mol Genet. 2025 May 6;34(10):843-851. [Abstract]
- Epigenomics. 2024;16(15-16):1097-1115. [Abstract]
- Cell Biochem Biophys. 2026 Jun 3. [Abstract]
- Cell Biochem Biophys. 2025 Jun;83(2):2415-2430. [Abstract]
- Clin Transl Oncol. 2023 May;25(5):1378-1388. [Abstract]
- J Nat Med. 2026 May 13. [Abstract]
- Clin Med Insights Oncol. 2024 Apr 15:18:11795549241244783. [Abstract]
- Biochem Biophys Res Commun. 2026 May 28:815:153580. [Abstract]
- Mutat Res. 2024 Jul-Dec:829:111873. [Abstract]
- Ann Hematol. 2024 Nov;103(11):4511-4524. [Abstract]
- Drug Chem Toxicol. 2026 Jan 29:1-10. [Abstract]
- Exp Ther Med. 2023 Sep 14;26(5):507. [Abstract]
- Exp Ther Med. 2023 Apr 12;25(6):246. [Abstract]
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- Biomed Pharmacother. 2024 Aug:177:117081. [Abstract]
- Heliyon. 2024 Jun 26;10(13):e33674. [Abstract]
- Research Square Preprint. 2024 Mar 18.
- SSRN. 2023 Dec 20.
- Biomed Pharmacother. 2023 Oct:166:115333. [Abstract]
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Flow Cytometry
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Cell Imaging/Staining
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Cell Imaging/Staining
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Cell Imaging/Staining
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Flow Cytometry
Biological Activity
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Preparation of BODIPY 581/591 C11 working solution
1.1 Preparation of the stock solution
Dissolve BODIPY 581/591 C11 in DMSO to obtain 10 mM of BODIPY 581/591 C11 stock solution.
Note: It is recommended to store the stock solution at -20°C -80°C away from light and avoid repetitive freeze-thaw cycles.
1.2 Preparation of BODIPY 581/591 C11 working solution
Dilute the stock solution in serum-free cell culture medium or PBS to obtain 2-10 μM of BODIPY 581/591 C11 working solution.
Note: Please adjust the concentration of BODIPY 581/591 C11 working solution according to the actual situation.
2. Cell staining
2.1 Cell preparation:
For suspension cells: Centrifuge at 1000 g at 4°C for 3-5 minutes and then discard the supernatant. Wash twice with PBS, 5 minutes each time.
For adherent cells: Discard the cell culture medium, and add trypsin to dissociate cells to make a single-cell suspension. Centrifuge at 1000 g at 4°C for 3-5 minutes and then discard the supernatant. Wash twice with PBS, 5 minutes each time.
2.2 Add 1 mL of BODIPY 581/591 C11 working solution, and then incubate at room temperature for 30 minutes.
2.3 Centrifuge at 400 g at 4°C for 3-4 minutes and then discard the supernatant.
2.4 Wash twice with PBS, 5 minutes each time.
2.5 Resuspend cells with serum-free cell culture medium or PBS, and then detect by fluorescence microscope or flow cytometer.
Precautions
1. It is recommended to store the stock solution at -20°C or -80°C away from light and avoid repetitive freeze-thaw cycles.
2. Please adjust the concentration of BODIPY 581/591 C11 working solution according to the actual situation.
3. This product is for R&D use only, not for drug, household, or other uses.
4. For your safety and health, please wear a lab coat and disposable gloves to operate.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 217075-36-0
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Appearance Solid
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Molecular Weight 504.42
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Formula C30H35BF2N2O2
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Color Brown to black
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SMILES
O=C(CCCCCCCCCCC1=CC=C2C=C3C=CC(/C=C/C=C/C4=CC=CC=C4)=[N]3[B+3]([F-])([N-]21)[F-])O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (155)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
2025 Dec 3;10(1):394. PMID: 41330906 -
Signal Transduct Target Ther
CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties. [Abstract]2023 Aug 16;8(1):302. PMID: 37582812
BODIPY 581/591 C11 purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2023 Aug 16;8(1):302. [Abstract]
Flow cytometry analysis for lipid reactive oxygen species generation in KYSE410 and KYSE450 cells treated with D-lactate. 5 μM BODIPY 581/591 was added to cells and incubated at 37 °C for 30 min.
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Adv Mater
Biomimetic Nanomotors for Deep Ischemia Penetration and Ferroptosis Inhibition in Neuroprotective Therapy of Ischemic Stroke. [Abstract]2025 Jan;37(3):e2409176. PMID: 39600046 -
Adv Mater
2023 Nov;35(48):e2306469. PMID: 37669827 -
Cell Host Microbe
Rothia mucilaginosa membrane vesicles stabilize labile iron to alleviate UVB-induced ferroptosis. [Abstract]2026 Jan 14;34(1):35-51.e9. PMID: 41500222 -
Drug Resist Updat
Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer. [Abstract]2023 May:68:100936. PMID: 36764075 -
Sci Bull
Topology regulation of nanomedicine for autophagy-augmented ferroptosis and cancer immunotherapy. [Abstract]2023 Jan 15;68(1):77-94. PMID: 36621435 -
Nat Commun
Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies. [Abstract]2025 Dec 13. PMID: 41390693
BODIPY 581/591 C11 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Dec 13. [Abstract]
Flow cytometry detection of lipid peroxidation in cells under different treatment groups. (BODIPY 581/591, 5 μM, 20 min.)
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Nat Commun
ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression. [Abstract]2025 Jul 1;16(1):5491. PMID: 40593779 -
ACS Nano
Realistic Nanoplastics Induced Pulmonary Damage via the Crosstalk of Ferritinophagy and Mitochondrial Dysfunction. [Abstract]2024 Jul 2;18(26):16790-16807. PMID: 38869479 -
ACS Nano
Thermoresponsive Ozone-Enriched Spray Gel for Postsurgical Treatment of Hepatocellular Carcinoma. [Abstract]2023 Feb 28;17(4):3518-3527. PMID: 36763050 -
Redox Biol
S100A9 modulates USP7-mediated stabilization of NCOA4 to promote ferroptosis in sepsis-associated acute lung injury. [Abstract]2026 Jun 21:95:104271. PMID: 42330601 -
Gut Microbes
Creatine-mediated ferroptosis inhibition is involved in the intestinal radioprotection of daytime-restricted feeding. [Abstract]2025 Dec;17(1):2489072. PMID: 40205678 -
J Nanobiotechnology
Targeted tumor cell-intrinsic CTRP6 biomimetic codelivery synergistically amplifies ferroptosis and immune activation to boost anti-PD-L1 immunotherapy efficacy in lung cancer. [Abstract]2025 Jun 2;23(1):409. PMID: 40457410 -
J Nanobiotechnology
Acidity-activatable dynamic hybrid nanoplatforms derived from extracellular vesicles of M1 macrophages enhance cancer immunotherapy through synergistic triple immunotherapy. [Abstract]2024 Jul 20;22(1):430. PMID: 39033108 -
Acta Pharm Sin B
THBru ameliorates atherosclerosis by inhibiting endothelial ferroptosis via regulation of the super-enhancer-associated ABCC1. [Abstract]2025 Dec;15(12):6461-6477. PMID: 41477343 -
J Exp Clin Cancer Res
Inhibition of RACGAP1 sensitizes triple-negative breast cancer cells to ferroptosis by regulating CPT1A-dependent fatty acid metabolism. [Abstract]2025 Dec 24;44(1):323. PMID: 41444950 -
J Exp Clin Cancer Res
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation. [Abstract]2025 Dec 29;44(1):329. PMID: 41462308 -
J Exp Clin Cancer Res
PSMA-targeted theranostic nanoplatform achieves spatiotemporally precise therapy and triggers ferroptosis in prostate cancer treatment. [Abstract]2025 Sep 30;44(1):272. PMID: 41029459 -
Adv Sci (Weinh)
TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy. [Abstract]2026 Apr;13(22):e21997. PMID: 41704008 -
Adv Sci (Weinh)
Lysosome-Featured Cell Aggregate-Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post-Irradiation Endothelial Ferroptosis for Mandibular Regeneration. [Abstract]2025 Sep;12(34):e05070. PMID: 40546115
BODIPY 581/591 C11 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep;12(34):e05070. [Abstract]
Immunostaining for GPX4 (green) with nuclei stained with DAPI (blue), or fluorescent staining of C11-BODIPY (red, non-oxidized; green, oxidized) with nuclei stained with Hoechst (blue) in HUVECs. (BODIPY 581/591, 10 μM, 30 min.)
BODIPY 581/591 C11 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep;12(34):e05070. [Abstract]
Immunostaining for glutathione peroxidase 4 (GPX4) (green) with nuclei stained with DAPI (blue), or fluorescent staining of C11-BODIPY (red, non-oxidized; green, oxidized) with nuclei stained with Hoechst (blue) in HUVECs. Scale bars, 10 µm. (BODIPY 581/591, 10 μM, 30 min.)
BODIPY 581/591 C11 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Sep;12(34):e05070. [Abstract]
Fluorescent staining of live (Calcein-AM, green) and dead (PI, red) HUVECs measured by cell viability/cytotoxicity assay, or C11-BODIPY (red, non‐oxidized; green, oxidized) in HUVECs with nuclei stained with Hoechst (blue). Scale bars, 100 µm (up) and 10 µm (down). (BODIPY 581/591, 10 μM, 30 min.)
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Adv Sci (Weinh)
Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8-AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma. [Abstract]2025 Aug;12(30):e01042. PMID: 40391780 -
MedComm (2020)
A novel circPIK3C2A/miR‐31‐5p/TFRC axis drives ferroptosis and accelerates myocardial injury. [Abstract]2024 Jun 5;5(6):e571. PMID: 38840772 -
Adv Sci (Weinh)
Sonodynamic Therapy of NRP2 Monoclonal Antibody-Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy-Dependent Ferroptosis. [Abstract]2023 Oct;10(30):e2303872. PMID: 37661565 -
Sci Adv
A robust adhesive microneedle for oral infections therapy via synergistic antibacterial and neutrophil-macrophage axis immunomodulation. [Abstract]2026 May;12(18):eaee4401. PMID: 42054454 -
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J Control Release
Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer. [Abstract]2024 Sep 18:375:422-437. PMID: 39278355 -
Cell Death Dis
SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma. [Abstract]2025 Apr 7;16(1):261. PMID: 40195331 -
Cell Death Dis
Enhanced ferroptosis sensitivity promotes the formation of highly myopic cataract via the DDR2-Hippo pathway. [Abstract]2025 Feb 3;16(1):64. PMID: 39900894 -
Small
Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization. [Abstract]2023 Mar;19(10):e2206415. PMID: 36627264 -
NPJ Biofilms Microbiomes
Lactobacillus amylovorus extracellular vesicles mitigate mammary gland ferroptosis via the gut-mammary gland axis. [Abstract]2025 Jun 21;11(1):113. PMID: 40544167 -
Phytomedicine
CBX5 loss drives Pl3Kδ inhibitor resistance in mantle cell lymphoma and propolis restores sensitivity by inducing CBX5-mediated ferroptosis. [Abstract]2025 Jul 25:143:156911. PMID: 40466505 -
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Mater Today Bio
NIR-elicited nanoplatform amplifies cancer ferrotherapy in uveal melanoma via synergistic ferroptosis induction and glucose metabolism intervention. [Abstract]2026 May 6:38:103208. PMID: 42170235 -
Mater Today Bio
Umbilical cord mesenchymal stem cells and their extracellular vesicles attenuate cryopreservation-induced ovarian injury via the suppression of ferroptosis in an in vitro culture system. [Abstract]2026 Feb 23:37:102965. PMID: 41800454 -
J Hazard Mater
Isobavachalcone confers protection against Cryptococcus neoformans-induced ferroptosis in Caenorhabditis elegans via lifespan extension and GSH-GPX-1 axis modulation. [Abstract]2025 Jul 15:492:137969. PMID: 40154123 -
J Hazard Mater
Exposure to 6PPD-Q induces dysfunctions of ovarian granulosa cells: Its potential role in PCOS. [Abstract]2025 Mar 15:486:137037. PMID: 39764971 -
Cell Death Discov
O-GlcNAcylation of glutaminase isoform KGA inhibits ferroptosis through activation of glutaminolysis in hepatoblastoma. [Abstract]2025 Apr 9;11(1):160. PMID: 40204725 -
J Transl Med
Gallic acid alleviates exercise-induced muscle damage by inhibiting mitochondrial oxidative stress and ferroptosis. [Abstract]2025 Jan 8;23(1):30. PMID: 39780143 -
J Colloid Interface Sci
Redox-driven hybrid nanoenzyme dynamically activating ferroptosis and disulfidptosis for hepatocellular carcinoma theranostics. [Abstract]2025 Sep:693:137611. PMID: 40253866 -
Basic Res Cardiol
Antimicrobial peptide CRAMP/LL-37 mediates ferroptosis resistance in cardiomyocytes by inhibiting cathepsin L. [Abstract]2025 Jun 15. PMID: 40517353 -
Oncogene
CBX3 promotes multidrug resistance by suppressing ferroptosis in colorectal carcinoma via the CUL3/NRF2/GPX2 axis. [Abstract]2025 Jun;44(22):1678-1693. PMID: 40089640 -
Apoptosis
A pH-responsive silver nanoparticle platform overcomes MEK inhibitor resistance in neurofibroma via triacsin C-mediated lipid metabolic reprogramming. [Abstract]2026 May 24;31(6):150. PMID: 42177691 -
Int J Biol Macromol
2026 May:361:151921. PMID: 41967541 -
Int J Biol Macromol
2025 Dec 30;339(Pt 2):149976. PMID: 41478474 -
Int J Biol Macromol
2025 Dec 4;337(Pt 1):149424. PMID: 41352507 -
Int J Nanomedicine
Magnetic Microbubbles Combined with ICG-Loaded Liposomes for Synergistic Mild-Photothermal and Ferroptosis-Enhanced Photodynamic Therapy of Melanoma. [Abstract]2025 Mar 10:20:2901-2921. PMID: 40093542 -
Mol Med
CKS2 induces autophagy-mediated glutathione metabolic reprogramming to facilitate ferroptosis resistance in colon cancer. [Abstract]2024 Nov 15;30(1):219. PMID: 39548421 -
Free Radic Biol Med
TFEB-nuclear translocation promotes BNIP3-mediated mitophagy and alleviates oxidative stress and ferroptosis in acute pancreatitis. [Abstract]2025 Nov 23:243:398-413. PMID: 41290101 -
Free Radic Biol Med
Resveratrol induces ferroptosis in triple-negative breast cancer through NEDD4L-mediated GPX4 ubiquitination and degradation. [Abstract]2025 Aug 1:235:231-247. PMID: 40316059 -
Free Radic Biol Med
FATP5 deficiency alleviates MASH via remodeling hepatic lipid composition to suppress ferroptosis. [Abstract]2025 Aug 19:240:170-182. PMID: 40840619 -
ACS Appl Mater Interfaces
Tumor-Targeted PLGA Nanospheres Enhance Therapeutic Effect of Lenvatinib in Hepatocellular Carcinoma via Photothermal and Photodynamic Therapy. [Abstract]2025 Aug 6;17(31):44922-44938. PMID: 40689931 -
J Med Chem
2024 Feb 22;67(4):2758-2776. PMID: 38295524 -
Genomics Proteomics Bioinformatics
The Indicine X-linked CYBBL237M Mutation Can Suppress Intracellular Infection with Tubercle Bacilli. [Abstract]2025 Dec 23:qzaf131. PMID: 41433053 -
Cancer Cell Int
Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer. [Abstract]2024 Jun 5;24(1):200. PMID: 38840243 -
Pharmaceutics
2024 Sep 13;16(9):1205. PMID: 39339241 -
J Ethnopharmacol
Dendrobine ameliorates non-alcoholic fatty liver disease by inhibiting mitochondrial fission through modulation of the Wnt5a/p-CaMKII/p-Drp1 signaling axis. [Abstract]2026 May 23:363:121445. PMID: 41763618 -
Virulence
Combination of isobavachalcone and amphotericin B has antifungal effect against Cryptococcus neoformans and protects host tissue damage by inhibiting ferroptosis. [Abstract]2025 Dec;16(1):2543981. PMID: 40828668 -
Neurosci Bull
Piezo1 Mediates Ultrasound-Stimulated Dopaminergic Neuron Protection via Synaptic Vesicle Recycling and Ferroptosis Inhibition. [Abstract]2025 May 29. PMID: 40439849 -
J Ethnopharmacol
Total extracts from Abelmoschus manihot (L.) alleviate radiation-induced cardiomyocyte ferroptosis via regulating redox imbalances mediated by the NOX4/xCT/GPX4 axis. [Abstract]2024 Nov 15:334:118582. PMID: 39009325 -
J Agric Food Chem
Analysis of the Antagonistic Effect of Dibutyl Phthalate on Magnaporthe oryzae through Bioassay and Omics Data. [Abstract]2025 Jul 30;73(30):18804-18821. PMID: 40674033 -
Eur J Med Chem
Discovery and optimization of indirubin derivatives as novel ferroptosis inducers for the treatment of colon cancer. [Abstract]2023 Dec 5:261:115829. PMID: 37801824 -
Ecotoxicol Environ Saf
Nanoplastics and Benzo[a]pyrene Co-pollution aggravates pulmonary ferroptosis via endoplasmic reticulum stress-triggered IRE1α liquid-liquid phase separation. [Abstract]2026 Jun 8:322:120347. PMID: 42259117 -
Ecotoxicol Environ Saf
Chlorfenapyr promotes mtROS-associated ferroptotic injury in cardiomyocytes and rat heart. [Abstract]2026 May:316:120144. PMID: 42000459 -
Ecotoxicol Environ Saf
Yttrium chloride induces ferroptosis in cardiomyocytes via iron accumulation and triggers cardiac lipid peroxidation and inflammation that cause heart adverse events in mice. [Abstract]2023 Sep 15:263:115279. PMID: 37480692 -
Biochem Pharmacol
Wedelolide A induces ferroptosis and apoptosis in gastric cancer via keap1/Nrf2 modulation and ROS generation. [Abstract]2026 Jan;243(Pt 1):117519. PMID: 41192684 -
Biochem Pharmacol
USP7 inhibitor P5091 enhances the antitumor efficacy of vemurafenib in BRAFV600E-mutant thyroid cancer via ferroptosis. [Abstract]2026 Jan;243(Pt 2):117522. PMID: 41207567 -
Biochem Pharmacol
Estradiol alleviated chemotherapy-induced premature ovarian failure by blocking the ferroptosis via activating ESR2/Sirt1/Nrf2 pathway. [Abstract]2025 Oct 29;243(Pt 1):117481. PMID: 41173058 -
Biochem Pharmacol
Oncogenic GOPC-ROS1 fusion promotes the formation of lymphatic malformations by impairing tight junction and its crizotinib resistance through repressing ferroptosis. [Abstract]2025 Aug 15;242(Pt 1):117243. PMID: 40819798 -
Biochem Pharmacol
WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma. [Abstract]2025 Mar:233:116790. PMID: 39894307 -
Biochem Pharmacol
Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells. [Abstract]2025 Mar:233:116763. PMID: 39832669 -
Life Sci
Dapagliflozin attenuates diabetic cardiomyopathy via NRF2 protein upregulation-driven glutathione synthesis to inhibit myocardial ferroptosis. [Abstract]2025 Oct 1:378:123819. PMID: 40550388 -
Life Sci
Iron deficiency anemia and platelet dysfunction: A comprehensive analysis of the underlying mechanisms. [Abstract]2024 Aug 15:351:122848. PMID: 38885879 -
Life Sci
Exploration and validation of therapeutic molecules for rheumatoid arthritis based on ferroptosis-related genes. [Abstract]2024 Aug 15:351:122780. PMID: 38866217 -
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Inflamm Res
Erianin protects chondrocytes against IL-1β-induced oxidative stress and ferroptosis by activating GPX4/STING signaling in osteoarthritis. [Abstract]2026 Jan 14;75(1):19. PMID: 41533098 -
Transl Res
Trimethylamine N-oxide exacerbates myocardial ischemia-reperfusion injury by sustaining PERK/eIF2α activation and impairing ferredoxin reductase-dependent mitochondrial function. [Abstract]2026 Jun:292:26-39. PMID: 42001995 -
Pharm Biol
Sauchinone attenuates UVB-induced photoaging by suppressing oxidative stress and ferroptosis through activation of the Keap1-Nrf2 pathway in dermal fibroblasts. [Abstract]2026 Dec;64(1):764-782. PMID: 42165632 -
Oncogenesis
ACSL6 modulates docosahexaenoic acid-induced cytotoxicity to potentiate chemotherapy response in colorectal and breast cancer. [Abstract]2025 Nov 21;14(1):45. PMID: 41271644 -
Colloids Surf B Biointerfaces
3D printed GelMA/HAMA based mechanical microenvironment boosted PDAC chemoresistance via NRF2-repressed ferroptosis. [Abstract]2025 Oct:254:114816. PMID: 40446539 -
Clin Epigenetics
2025 Jul 7;17(1):120. PMID: 40624511 -
ACS Appl Bio Mater
Relaxation Suppressed Exchange Tuning MRI Integrated with Manganese-Based Nanozyme Probes for Ferroptosis Induction and GPX4 Monitoring. [Abstract]2026 May 4;9(9):4297-4313. PMID: 41979062 -
Int Immunopharmacol
METTL3-mediated MSRB3 m6A modification accelerates hypoxia-induced cardiomyocyte ferroptosis by inhibiting mitochondrial oxidative phosphorylation. [Abstract]2025 Oct 10:163:115268. PMID: 40743621 -
Int Immunopharmacol
Unraveling the crucial role of SDF-1 in osteoarthritis progression: IL6/HIF-1α positive feedback and chondrocyte ferroptosis. [Abstract]2025 Apr 16:152:114400. PMID: 40058106 -
Biol Direct
SH3BGRL3 promotes radioresistance and immune evasion in triple-negative breast cancer by regulating Rab27a. [Abstract]2026 Apr 27;21(1):96. PMID: 42045928 -
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Chem Biol Interact
Oridonin exposure induces testicular impairment through regulating ferroptosis via HIF-1α/HO-1 activation and STUB1-driven GPX4 ubiquitination-dependent degradation. [Abstract]2026 Jan 5:423:111838. PMID: 41265811 -
Food Sci Nutr
Traditional Chinese Herbal Formula XuMingZhuSan Alleviates Neuronal Ferroptosis in Rats After Stroke by Activating the NRF2/GPX4/SLC7A11 Pathway. [Abstract]2026 Mar 10;14(3):e71495. PMID: 41822239 -
Food Sci Nutr
Dauricine Inhibits Macrophages M2 Polarization and Regulates the Progression and Ferroptosis via HCK/IDO1 in Urinary Bladder Cancer. [Abstract]2025 Dec 21;13(12):e71341. PMID: 41438182 -
Mol Med Rep
Quercetin attenuates the symptoms of osteoarthritis in vitro and in vivo by suppressing ferroptosis via activation of AMPK/Nrf2/Gpx4 signaling. [Abstract]2025 Mar;31(3):60. PMID: 39717946 -
Biochim Biophys Acta Mol Basis Dis
Lipocalin-2 inhibition alleviates neural injury by microglia ferroptosis suppression after experimental intracerebral hemorrhage in mice via enhancing ferritin light chain expression. [Abstract]2024 Oct;1870(7):167435. PMID: 39067535 -
Sci Rep
XMD8-92 and JWG-045 exhibit anti-ferroptotic activities, independently of inhibiting ERK5. [Abstract]2026 Feb 28. PMID: 41764307 -
Sci Rep
Icariin alleviates cisplatin-induced premature ovarian failure by inhibiting ferroptosis through activation of the Nrf2/ARE pathway. [Abstract]2024 Jul 27;14(1):17318. PMID: 39068256 -
Cancers (Basel)
High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway. [Abstract]2023 Apr 23;15(9):2427. PMID: 37173894 -
J Cell Mol Med
2026 Apr;30(8):e71147. PMID: 41998836 -
Cell Signal
NCAPG confers ferroptosis resistance of hepatocellular carcinoma through NSUN2-mediated m5C modification. [Abstract]2026 Feb:138:112256. PMID: 41260238 -
J Dairy Sci
Heat shock protein B1-mediated ferroptosis regulates mitochondrial dysfunction in adipose tissue of ketotic dairy cows. [Abstract]2025 Jul;108(7):7815-7836. PMID: 40348370 -
J Cell Mol Med
Aryl Hydrocarbon Receptor Alleviates Hepatic Fibrosis by Inducing Hepatic Stellate Cell Ferroptosis. [Abstract]2024 Dec;28(23):e70278. PMID: 39654034 -
J Inflamm Res
Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury. [Abstract]2026 Jun 19:19:596461. PMID: 42345001 -
J Inflamm Res
Cardamonin Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis Through Promoting STAT3 Signaling. [Abstract]2024 Nov 15:17:8861-8879. PMID: 39569022 -
Brain Res Bull
METTL3-YTHDF1 axis drives BCL-3 m6A methylation to promote the ferroptosis of brain microvascular endothelial cells during intracerebral hemorrhage. [Abstract]2025 Sep:229:111434. PMID: 40523531 -
iScience
SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression. [Abstract]2025 Jul 25;28(8):113097. PMID: 40822351 -
iScience
Melanin-like nanoparticles alleviate ischemia-reperfusion injury in the kidney by scavenging reactive oxygen species and inhibiting ferroptosis. [Abstract]2024 Mar 14;27(4):109504. PMID: 38632989 -
Fish Shellfish Immunol
Perfluorooctanoic acid (PFOA) exposure induced ferroptosis through the PPARα/FABP7 signaling pathway in the liver of spotted sea bass (Lateolabrax maculatus). [Abstract]2025 Oct 8:168:110908. PMID: 41067592 -
Naunyn Schmiedebergs Arch Pharmacol
Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine. [Abstract]2025 Dec 18. PMID: 41408483 -
Naunyn Schmiedebergs Arch Pharmacol
Toosendanin promotes prostate cancer cell apoptosis, ferroptosis and M1 polarization via USP39-mediated PLK1 deubiquitination. [Abstract]2025 Mar 8. PMID: 40056202 -
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Skelet Muscle
Role and mechanism of myonectin in severe acute pancreatitis: a crosstalk between skeletal muscle and pancreas. [Abstract]2024 Dec 3;14(1):29. PMID: 39627746 -
Toxicol Appl Pharmacol
Inhibition of CDGSH iron‑sulfur domain 2 exhibits tumor-suppressing effects on diffuse large B-cell lymphoma (DLBCL) by inducing ferroptosis through the regulation of the NRF2/SLC7A11/GPX4 pathway. [Abstract]2024 Dec:493:117148. PMID: 39521147 -
Appl Biochem Biotechnol
OGT Silencing Protects against Trophoblast Ferroptosis in Gestational Diabetes Mellitus Via ELP3 O-GlcNAcylation Suppression. [Abstract]2026 Jan 8. PMID: 41504842 -
Photochem Photobiol Sci
TIMP3 deficiency accelerates UVB-induced HaCaT cell senescence by regulating ferroptosis. [Abstract]2025 Mar;24(3):499-509. PMID: 40117061 -
Int J Biochem Cell Biol
TFAP2C/FLT3 axis reduces ferroptosis in breast cancer cells by inhibiting mitochondrial autophagy. [Abstract]2024 Dec:177:106691. PMID: 39536858 -
Mol Cell Endocrinol
2026 Mar:613:112721. PMID: 41422938 -
Atheroscler Plus
The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells. [Abstract]2025 Jun 6:61:1-11. PMID: 40547949 -
J Neurooncol
Mifepristone achieves tumor suppression and ferroptosis through PR/p53/HO1/GPX4 axis in meningioma cells. [Abstract]2025 Apr;172(2):377-386. PMID: 39751705 -
Cardiovasc Toxicol
LncRNA AK020546 Alleviates Myocardial Ischemia-Reperfusion Injury via Suppressing METTL14/m6A/MST1 Axis-Mediated Ferroptosis. [Abstract]2025 Aug;25(8):1169-1180. PMID: 40465027 -
Adv Biol (Weinh)
Paliperidone Inhibits Ferroptosis Mediated by Autophagy in Renal Tubular Epithelial Cells by Targeting CHAC1. [Abstract]2025 Aug;9(8):e2400648. PMID: 40259582 -
J Immunol Res
miR-1 Inhibits the Ferroptosis of Chondrocyte by Targeting CX43 and Alleviates Osteoarthritis Progression. [Abstract]2023 Jun 30:2023:2061071. PMID: 37425490 -
Hum Mol Genet
LRP8 inhibits bladder cancer cell ferroptosis by activating the Wnt/β-catenin-SCD1 positive feedback loop. [Abstract]2025 May 6;34(10):843-851. PMID: 39989004 -
Epigenomics
LINC01232 promotes ARNTL2 transcriptional activation and inhibits ferroptosis of CRC cells through p300/H3K27ac. [Abstract]2024;16(15-16):1097-1115. PMID: 39268727 -
Cell Biochem Biophys
2026 Jun 3. PMID: 42234252 -
Cell Biochem Biophys
IRF7 Activates LCN2 Transcription to Enhance LPS-Induced Acute Lung Injury by Inducing Macrophage Ferroptosis and M1 Polarization. [Abstract]2025 Jun;83(2):2415-2430. PMID: 39738844 -
Clin Transl Oncol
Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability. [Abstract]2023 May;25(5):1378-1388. PMID: 36484954 -
J Nat Med
Asarinin attenuates ferroptosis resistance by inhibiting the activity of S-adenosyl homocysteine hydrolase in lung cancer. [Abstract]2026 May 13. PMID: 42126473 -
Clin Med Insights Oncol
MiR-339-5p Inhibits Ferroptosis by Promoting Autophagic Degradation of FTH1 Through Targeting ATG7 in Liver Cancer Cells. [Abstract]2024 Apr 15:18:11795549241244783. PMID: 38628842 -
Biochem Biophys Res Commun
Glabridin attenuates diabetic cardiomyopathy by activating AMPK to suppress ferroptosis and TGF-β-mediated myocardial fibrosis. [Abstract]2026 May 28:815:153580. PMID: 41905164 -
Mutat Res
Transcription factor NFYA inhibits ferroptosis in lung adenocarcinoma cells by regulating PEBP1. [Abstract]2024 Jul-Dec:829:111873. PMID: 38996537 -
Ann Hematol
Licochalcone A decreases cancer cell proliferation and enhances ferroptosis in acute myeloid leukemia through suppressing the IGF2BP3/MDM2 cascade. [Abstract]2024 Nov;103(11):4511-4524. PMID: 39264435 -
Drug Chem Toxicol
Targeting the SP1/ACSL4 axis attenuates ferroptosis in trastuzumab-induced cardiotoxicity. [Abstract]2026 Jan 29:1-10. PMID: 41607232 -
Exp Ther Med
Salidroside inhibits renal ischemia/reperfusion injury‑induced ferroptosis by the PI3K/AKT signaling pathway. [Abstract]2023 Sep 14;26(5):507. PMID: 37822587 -
Exp Ther Med
Acrylamide induces human chondrocyte cell death by initiating autophagy‑dependent ferroptosis. [Abstract]2023 Apr 12;25(6):246. PMID: 37153903 -
Oncol Lett
Lung squamous cell carcinoma downregulates haptoglobin expression to inhibit M2 macrophage ferroptosis via the hemoglobin-dependent CD163/HO-1 pathway. [Abstract]2026 Mar 30;31(5):203. PMID: 41987865 -
Biol Pharm Bull
Kaempferol Inhibits Ferroptosis in Lung Epithelial Cells in LPS-Induced Acute Lung Injury via m5C Methylation of TFRC. [Abstract]2025;48(9):1343-1350. PMID: 40930835 -
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Biomed Pharmacother
Berberine as a novel ACSL4 inhibitor to suppress endothelial ferroptosis and atherosclerosis. [Abstract]2024 Aug:177:117081. PMID: 38971008 -
Heliyon
Induction of ferroptosis by brucine suppresses gastric cancer progression through the p53-mediated SLCA711/ALOX12 axis. [Abstract]2024 Jun 26;10(13):e33674. PMID: 39050447 -
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Biomed Pharmacother
Celastrol alleviated acute kidney injury by inhibition of ferroptosis through Nrf2/GPX4 pathway. [Abstract]2023 Oct:166:115333. PMID: 37598476
Solvent & Solubility
DMSO : 12.5 mg/mL (24.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9825 mL | 9.9124 mL | 19.8247 mL | 49.5619 mL |
| 5 mM | 0.3965 mL | 1.9825 mL | 3.9649 mL | 9.9124 mL | |
| 10 mM | 0.1982 mL | 0.9912 mL | 1.9825 mL | 4.9562 mL | |
| 15 mM | 0.1322 mL | 0.6608 mL | 1.3216 mL | 3.3041 mL | |
| 20 mM | 0.0991 mL | 0.4956 mL | 0.9912 mL | 2.4781 mL |