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WRW4 

Cat. No.: HY-P1119 Purity: 99.02%
Handling Instructions

WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide.

For research use only. We do not sell to patients.

WRW4 Chemical Structure

WRW4 Chemical Structure

CAS No. : 878557-55-2

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1 mg USD 100 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

In Vitro

WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1104.27

Formula

C₆₁H₆₅N₁₅O₆

CAS No.

878557-55-2

Sequence

Trp-Arg-Trp-Trp-Trp-Trp-NH2

Sequence Shortening

WRWWWW-NH2

SMILES

O=C(N[[email protected]@H](CCCNC(N)=N)C(N[[email protected]@H](CC1=CNC2=CC=CC=C12)C(N[[email protected]@H](CC3=CNC4=CC=CC=C34)C(N[[email protected]@H](CC5=CNC6=CC=CC=C56)C(N[[email protected]@H](CC7=CNC8=CC=CC=C78)C(N)=O)=O)=O)=O)=O)[[email protected]](CC9=CNC%10=CC=CC=C9%10)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Protect from light, stored under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

References
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Keywords:

WRW4WRW 4WRW-4OthersAbeta42superoxidegenerationneutrophilsmigrationmacrophagesphosphorylationInhibitorinhibitorinhibit

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WRW4
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HY-P1119
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