2. GPCR/G Protein
  3. Formyl Peptide Receptor (FPR)
  4. WRW4 TFA

WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of WRW4 TFA:

Other Forms of WRW4 TFA:

WRW4 TFA Related Antibodies

Top Publications Citing Use of Products

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2023 Jan 19;28(1):4.  [Abstract]

    Inhibition of elevated FPR2 is protective against kidney injury. The left renal pedicle of the rat was clamped for 45 min to induce IRI. The right kidney was removed before releasing the clamps. WRW4 (10 mg/kg; single dose) was administered intravenously 30 min before surgery. Serum or kidney tissues were collected 24 h after surgery. Kidney tissues were sectioned for histological examination and TUNEL staining. Scale bar, 100 μm. TUNEL staining results showed a decrease in the number of apoptotic renal tubular cells in the WRW4 pretreatment group compared with the surgical group.

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: Cell Mol Biol Lett. 2023 Jan 19;28(1):4.  [Abstract]

    Inhibition of FPR2 reduces neutrophil infiltration in IRI kidneys. The left renal pedicle of the rat was clamped for 45 min to induce IRI. The right kidney was removed before releasing the clamps. WRW4 (10 mg/kg; single dose) was administered intravenously 30 min before surgery. Kidney tissues were collected 24 h after surgery. A Immunochemistry staining of CD68+ macrophages and MPO+ neutrophils. Scale bar, 100 μm.

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: Cancer Res. 2022 Aug 16;82(16):2887-2903.  [Abstract]

    Detection of PLD activity and PA production in the indicated cells. Cells were treated with cyclosporine H (5 μmol/L; FPR1 inhibitor) or WRW4 (10 μmol/L; FPR2 inhibitor) for 1 hour. The fold increases after D-AS2 overexpression and fold decreases after D-AS2 depletion are shown.

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2022 Aug 31;70(34):10532-10542.  [Abstract]

    Positive expression of p65 in liver tissue was observed by immunofluorescence staining under a laser scanning confocal microscope. The p65 cells were marked in red, and the nucleus was stained with 4′,6-diamidino-2-phenylindole (DAPI) in blue. Scale bars = 50 μm. The results showed that the expression level of p65 within the hepatocytes' nuclei was elevated in the CRS group rats; in the CRS + CGA group, the p65 expression level was reduced; furthermore, this effect of CGA was reversed by WRW4 (0.1 mg/kg; i.p.).

    WRW4 TFA purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2022 Aug 31;70(34):10532-10542.  [Abstract]

    Levels of serum RvD1 and RvD1 in liver tissue. ELISA results showed that RvD1 levels in serum and liver were significantly lower in CRS rats than in CON rats, and significantly higher in CGA-treated rats; this effect was prevented by WRW4 (0.1 mg/kg; i.p.).

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    WRW4 TFA, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 TFA specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

    In Vitro

    WRW4 TFA inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 TFA specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    WRW4 TFA Related Antibodies
    Molecular Weight

    1218.29

    Formula

    C63H66F3N15O8
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    WRW4 TFA Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    WRW4WRW 4WRW-4Formyl Peptide Receptor (FPR)Inhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Requested Quantity *

    Applicant Name *

    		 

    Salutation

    Email Address *

    		 

    Phone Number *

    Department

    		 

    Organization Name *

    City

    State

    Country or Region *

    		      

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    WRW4 TFA
    Cat. No.:
    HY-P1119A
    Quantity:
    MCE Japan Authorized Agent:

    Customer Review

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Product Name

    		  

    Lot #

    Applicant Name *

    		 

    Email Address *

    Phone Number

    		 

    Department *

    Organization Name *

    		 

    Country or Region *

    Remarks

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.