Cat. No.: HY-N4126

6-Demethoxytangeretin

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons.

For research use only. We do not sell to patients.

Purity: 99.37%
CAS No.: 6601-66-7
Formula: C₁₉H₁₈O₆
Molecular Weight:342.34

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

6-Demethoxytangeretin Chemical Structure

CAS No.: 6601-66-7

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All p38 MAPK Isoforms :

All Interleukin Related Isoforms :

All ERK Isoforms :

All JNK Isoforms :

All JAK Isoforms :

All STAT Isoforms :

All Akt Isoforms :

In Vitro

6-Demethoxytangeretin (0.8-20 μM; 1-6.5 h) inhibits the expression and production of inflammatory factors such as IL-6, as well as the phosphorylation of ALK and MAPK in HMC-1 cells stimulated by Phorbol 12-myristate 13-acetate (HY-18739) and Calcimycin (HY-N6687)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

HMC-1 cells stimulated by Phorbol 12-myristate 13-acetate (HY-18739) and Calcimycin (HY-N6687)
Concentration:

0.8, 4 and 20 μM
Incubation Time:

Pretreated with 30 min, then co-incubation for 6 h
Result:

Suppressed the mRNA levels of TNFα, CFS2, IL6 and IL8 at 4 or 20 µM.

Western Blot Analysis^[1]

Cell Line:

HMC-1 cells stimulated by Phorbol 12-myristate 13-acetate (HY-18739) and Calcimycin (HY-N6687)
Concentration:

0.8, 4 and 20 μM
Incubation Time:

Pretreated with 30 min, then co-incubation for 30 min
Result:

Apparently suppressed phosphorylation of ERK1/2, JNK1/2 and p38.
Suppressed phosphorylation of NPM-ALK, JAK2, STAT3, AKT and PLCγ1 in a dose dependent manner.

Chemical Information

CAS No. 6601-66-7
Appearance Solid
Molecular Weight 342.34
Formula C₁₉H₁₈O₆
Color White to off-white
SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=CC(OC)=C13
Structure Classification
- Flavonoids
- Flavones
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

University of Edinburgh

2025 May 29.

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (36.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9211 mL

14.6054 mL

29.2107 mL

5 mM

0.5842 mL

2.9211 mL

5.8421 mL

10 mM

0.2921 mL

1.4605 mL

2.9211 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 1.25 mg/mL (3.65 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

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Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [Content Brief]

[2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9211 mL	14.6054 mL	29.2107 mL	73.0268 mL
	5 mM	0.5842 mL	2.9211 mL	5.8421 mL	14.6054 mL
	10 mM	0.2921 mL	1.4605 mL	2.9211 mL	7.3027 mL
	15 mM	0.1947 mL	0.9737 mL	1.9474 mL	4.8685 mL
	20 mM	0.1461 mL	0.7303 mL	1.4605 mL	3.6513 mL
	25 mM	0.1168 mL	0.5842 mL	1.1684 mL	2.9211 mL
	30 mM	0.0974 mL	0.4868 mL	0.9737 mL	2.4342 mL

Keywords

6-Demethoxytangeretin

1 Cited Publications

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6-Demethoxytangeretin

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Publications Citing Use of MedChemExpress (MCE) 6-Demethoxytangeretin

All p38 MAPK Isoforms

All Interleukin Related Isoforms

All ERK Isoforms

All JNK Isoforms

All JAK Isoforms

All STAT Isoforms