6-Demethoxytangeretin
Based on 1 publication(s) in Google Scholar
6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons.
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- Purity: 99.37%
- CAS No.: 6601-66-7
- 화학식: C19H18O6
- 분자량:342.34
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) 6-Demethoxytangeretin
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Biological Activity
6-Demethoxytangeretin (0.8-20 μM; 1-6.5 h) inhibits the expression and production of inflammatory factors such as IL-6, as well as the phosphorylation of ALK and MAPK in HMC-1 cells stimulated by Phorbol 12-myristate 13-acetate (HY-18739) and Calcimycin (HY-N6687)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HMC-1 cells stimulated by Phorbol 12-myristate 13-acetate (HY-18739) and Calcimycin (HY-N6687)
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Concentration:0.8, 4 and 20 μM
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Incubation Time:Pretreated with 30 min, then co-incubation for 6 h
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Result:Suppressed the mRNA levels of TNFα, CFS2, IL6 and IL8 at 4 or 20 µM.
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Cell Line:HMC-1 cells stimulated by Phorbol 12-myristate 13-acetate (HY-18739) and Calcimycin (HY-N6687)
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Concentration:0.8, 4 and 20 μM
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Incubation Time:Pretreated with 30 min, then co-incubation for 30 min
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Result:Apparently suppressed phosphorylation of ERK1/2, JNK1/2 and p38.
Suppressed phosphorylation of NPM-ALK, JAK2, STAT3, AKT and PLCγ1 in a dose dependent manner.
Chemical Information
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CAS No. 6601-66-7
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Appearance Solid
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분자량 342.34
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화학식 C19H18O6
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Color White to off-white
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SMILES
O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=CC(OC)=C13
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
용액&용해도
DMSO : 12.5 mg/mL (36.51 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [Content Brief]
[2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9211 mL | 14.6054 mL | 29.2107 mL | 73.0268 mL |
| 5 mM | 0.5842 mL | 2.9211 mL | 5.8421 mL | 14.6054 mL | |
| 10 mM | 0.2921 mL | 1.4605 mL | 2.9211 mL | 7.3027 mL | |
| 15 mM | 0.1947 mL | 0.9737 mL | 1.9474 mL | 4.8685 mL | |
| 20 mM | 0.1461 mL | 0.7303 mL | 1.4605 mL | 3.6513 mL | |
| 25 mM | 0.1168 mL | 0.5842 mL | 1.1684 mL | 2.9211 mL | |
| 30 mM | 0.0974 mL | 0.4868 mL | 0.9737 mL | 2.4342 mL |
6-Demethoxytangeretin Related Classifications
HY-N4126 Related Classifications
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