1. Anti-infection
    Apoptosis
    Autophagy
  2. Bacterial
    Fungal
    Apoptosis
    Autophagy
    Antibiotic
  3. Calcimycin

Calcimycin (Synonyms: A-23187; Antibiotic A-23187)

Cat. No.: HY-N6687 Purity: >99.0%
Handling Instructions

Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.

For research use only. We do not sell to patients.

Calcimycin Chemical Structure

Calcimycin Chemical Structure

CAS No. : 52665-69-7

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 256 In-stock
Estimated Time of Arrival: December 31
1 mg USD 75 In-stock
Estimated Time of Arrival: December 31
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis[1][2][3][4].

In Vitro

Calcimycin (A-23187) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

In Vivo

Calcimycin (A-23187) (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

Animal Model: Mice (ICR, 25-30 g)[5]
Dosage: 2.5 or 7.5 nM
Administration: Intrapleurally
Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
Clinical Trial
Molecular Weight

523.62

Formula

C₂₉H₃₇N₃O₆

CAS No.

52665-69-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (95.49 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9098 mL 9.5489 mL 19.0978 mL
5 mM 0.3820 mL 1.9098 mL 3.8196 mL
10 mM 0.1910 mL 0.9549 mL 1.9098 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

CalcimycinA-23187Antibiotic A-23187A23187A 23187Antibiotic A23187Antibiotic A 23187BacterialFungalApoptosisAutophagyAntibioticmycobacterialdivalentcationionophoreGram-positivebacteriaphosphorylationInhibitorinhibitorinhibit

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Calcimycin
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