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Diphenyleneiodonium chloride

(Synonyms: DPI)
60 Cited Publications
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Based on 60 publication(s) in Google Scholar

Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

For research use only. We do not sell to patients.

  • Purity: 99.85%
  • CAS No.: 4673-26-1
  • Formula: C12H8ClI
  • Molecular Weight:314.55
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

  • Diphenyleneiodonium chloride Chemical Structure
    Diphenyleneiodonium chloride Chemical Structure
  • Experimental Validation Results for Diphenyleneiodonium chloride
  • Experimental Validation Results for Diphenyleneiodonium chloride
  • Experimental Validation Results for Diphenyleneiodonium chloride
  • Experimental Validation Results for Diphenyleneiodonium chloride
  • Experimental Validation Results for Diphenyleneiodonium chloride
CAS No.: 4673-26-1
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Cell Imaging/StainingFlow CytometryWB
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All NADPH Oxidase Isoforms

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  • Diphenyleneiodonium chloride Chemical Structure
    Diphenyleneiodonium chloride Chemical Structure
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    Diphenyleneiodonium chloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 18;16(1):6621. [Abstract]

    Customer Validation
     Treatment with Diphenyleneiodonium chloride (DPI) inhibited GFP-ATG8a translocation to the tonoplast. The schematic diagram on the left illustrated the timing of DPI addition and the subsequent monensin treatment. Scale bar, 20 μm.

  • 1/16

    Diphenyleneiodonium chloride purchased from MedChemExpress. Usage Cited in: Mar Drugs. 2025 Mar 22;23(4):138. [Abstract]

    Customer Validation
     Effects of diphenyleneiodonium chloride (DPI, 0.1 µM) followed by 48 h treatment with GUA (5 nM) and OLA (3 µM), demonstrated a marked reduction in ROS levels and subsequent cell restoration.

  • 1/16

    Diphenyleneiodonium chloride purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Mar 25;21(1):218. [Abstract]

    Customer Validation
     Heated or unheated HCC cells were incubated with or without inhibitors of ROS: NAC (5 mM), MitoTEMPO (500 nM), Diphenyleneiodonium chloride (10 μM), or VAS2870 (10 μM). Apoptosis was quantified using Annexin V-FITC/PI staining and flow cytometry at 24 h after sublethal heat stress.

  • 1/16

    Diphenyleneiodonium chloride purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Mar 25;21(1):218. [Abstract]

    Customer Validation
     Heated or unheated HCC cells preincubated with or without inhibitors of NADPH oxidase: Diphenyleneiodonium chloride (10 μM) and VAS2870 (10 μM), MitoSOX fluorescence measured using flow cytometry at 6 h after sublethal heat stress.

  • 1/16

    Diphenyleneiodonium chloride purchased from MedChemExpress. Usage Cited in: Mediators Inflamm. 2020 Jun 6;2020:4321912. [Abstract]

    Customer Validation
     Western blot result shows that compared with the agonist-CD137 group, the phosphorylation level of NF-κB in the DPI group is significantly reduced, indicating the interaction between ROS and NF-κB.

  • Diphenyleneiodonium chloride