Polyether Antibiotics

Structural features of Polyether antibiotics include an exterior alkyl backbone that confers their lipophilic characteristics and an oxygen-rich internal cavity that can bind metal ions. They affect the targeted cells by changing the permeability of cellular membranes to cationic metal species that lead to changes in Na+/K+ gradient and an increase in the osmotic pressure inside the cell, causing swelling, vacuolization, and ultimately death of the bacterial cell. These antibiotics show a broad spectrum of bioactivity including antibacterial (both for drug-sensitive and drug-resistant bacteria), antifungal, anti-parasitic, antiviral and tumor cell cytotoxicity.

Polyether Antibiotics (5):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-100381

Nigericin sodium salt 28643-80-3 ≥98.0%

Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H⁺, K⁺, and Pb²⁺ ionophore, a NLRP3 activator.

Nigericin sodium salt	28643-80-3	≥98.0%
Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H⁺, K⁺, and Pb²⁺ ionophore, a NLRP3 activator.

HY-N6687

Calcimycin	52665-69-7	99.12%
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.

HY-100528

Nanchangmycin	65101-87-3	≥98.0%
Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

HY-100528A

Dianemycin	35865-33-9	98.80%
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

HY-N6687A

Calcimycin hemicalcium salt	59450-89-4
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.

Name
Email *

	Sorry, but the email address you supplied was invalid.