1. Natural Products
  2. Antibiotics
  3. Polyether Antibiotics

Polyether Antibiotics

Structural features of Polyether antibiotics include an exterior alkyl backbone that confers their lipophilic characteristics and an oxygen-rich internal cavity that can bind metal ions. They affect the targeted cells by changing the permeability of cellular membranes to cationic metal species that lead to changes in Na+/K+ gradient and an increase in the osmotic pressure inside the cell, causing swelling, vacuolization, and ultimately death of the bacterial cell. These antibiotics show a broad spectrum of bioactivity including antibacterial (both for drug-sensitive and drug-resistant bacteria), antifungal, anti-parasitic, antiviral and tumor cell cytotoxicity.

Polyether Antibiotics (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100381
    Nigericin sodium salt 28643-80-3 ≥98.0%
    Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H+, K+, and Pb2+ ionophore, a NLRP3 activator.
    Nigericin sodium salt
  • HY-N6687
    Calcimycin 52665-69-7 99.56%
    Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis.
    Calcimycin
  • HY-100528
    Nanchangmycin 65101-87-3 ≥98.0%
    Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
    Nanchangmycin
  • HY-100528A
    Dianemycin 35865-33-9 ≥98.0%
    Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.
    Dianemycin
  • HY-N6687A
    Calcimycin hemicalcium salt 59450-89-4
    Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.
    Calcimycin hemicalcium salt