1. Anti-infection
  2. Bacterial
  3. Dianemycin

Dianemycin (Synonyms: Nanchangmycin (free acid))

Cat. No.: HY-100528A Purity: >98.0%
Handling Instructions

Dianemycin (Nanchangmycin free acid), produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Dianemycin is a broad spectrum antiviral active against Zika virus.

For research use only. We do not sell to patients.

Dianemycin Chemical Structure

Dianemycin Chemical Structure

CAS No. : 35865-33-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 229 In-stock
Estimated Time of Arrival: December 31
2 mg USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 720 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Dianemycin (Nanchangmycin free acid), produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Dianemycin is a broad spectrum antiviral active against Zika virus[2].

IC50 & Target

Bacteria[1]
Zika virus[2]

In Vitro

Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria[1].
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types[2].

Molecular Weight

867.11

Formula

C₄₇H₇₈O₁₄

CAS No.

35865-33-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 155 mg/mL (178.75 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1533 mL 5.7663 mL 11.5326 mL
5 mM 0.2307 mL 1.1533 mL 2.3065 mL
10 mM 0.1153 mL 0.5766 mL 1.1533 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (2.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (2.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Dianemycin
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HY-100528A
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