1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Dianemycin

Dianemycin (Synonyms: Nanchangmycin free acid)

Cat. No.: HY-100528A Purity: ≥98.0%
Handling Instructions

Dianémycine (acide libre de nanchangmycine), un antibiotique polyéther produit par Streptomyces nanchangensis NS3226, inhibe les bactéries gram-positives. Nanchangmycine est un antiviral à large spectre actif contre le virus Zika.

Dianemycin (freie Säure von Nanchangmycin), ein Polyether-Antibiotikum, das durch Streptomyces nanchangensis NS3226 hergestellt wird, hemmt grampositive Bakterien. Nanchangmycin ist ein Breitspektrum-Antivirusmittel, das gegen das Zika-Virus wirkt.

Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

For research use only. We do not sell to patients.

Dianemycin Chemical Structure

Dianemycin Chemical Structure

CAS No. : 35865-33-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 334 In-stock
Estimated Time of Arrival: December 31
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 950 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2].

IC50 & Target

Bacteria[1]
Zika virus[2]

In Vitro

Dianemycin (Nanchangmycin) can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Dianemycin is active against drug resistant strains of malaria[1].
Dianemycin (Nanchangmycin) as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Dianemycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Dianemycin has low toxicity in these ranges. In addition, DENV is inhibited by Dianemycin across cell types[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

867.11

Formula

C₄₇H₇₈O₁₄

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 155 mg/mL (178.75 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1533 mL 5.7663 mL 11.5326 mL
5 mM 0.2307 mL 1.1533 mL 2.3065 mL
10 mM 0.1153 mL 0.5766 mL 1.1533 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.58 mg/mL (2.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.58 mg/mL (2.98 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DianemycinNanchangmycinBacterialAntibioticInhibitorinhibitorinhibit

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Dianemycin
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