1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Nanchangmycin

Nanchangmycin  (Synonyms: Nanchangmycin A)

Cat. No.: HY-100528 Purity: ≥98.0%
COA Handling Instructions

Nanchangmycine, un antibiotique polyéther produit par Streptomyces nanchangensis NS3226, inhibe les bactéries gram-positives. Nanchangmycine est un antiviral à large spectre actif contre le virus Zika.

Nanchangmycin, ein Polyether-Antibiotikum, das von Streptomyces nanchangensis NS3226 hergestellt wird, hemmt grampositive Bakterien. Nanchangmycin ist ein Breitspektrum-Antivirusmittel, das gegen das Zika-Virus wirkt.

Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria. Nanchangmycin is a broad spectrum antiviral active against Zika virus.

For research use only. We do not sell to patients.

Nanchangmycin Chemical Structure

Nanchangmycin Chemical Structure

CAS No. : 65101-87-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 376 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 376 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 385 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1045 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Nanchangmycin:

Top Publications Citing Use of Products
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  • Purity & Documentation

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Description

Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2].

IC50 & Target

Bacteria[1]
Zika virus[2]

In Vitro

Nanchangmycin can be used as a growth promotant in poultry and to cure coccidiosis in chickens. Nanchangmycin is active against drug resistant strains of malaria[1]. Nanchangmycin as a potent inhibitor of Zika virus (ZIKV) entry across all cell types tested including physiologically relevant primary cells. Nanchangmycin potently reduces infection of all three strains of ZIKV across all three cell types. The IC50s for infection are between 0.1 and 0.4 μM while Nanchangmycin has low toxicity in these ranges. In addition, DENV is inhibited by Nanchangmycin across cell types[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

889.10

Formula

C47H77NaO14

CAS No.
SMILES
Structure Classification
Source

S. nanchangesis

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (33.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1247 mL 5.6237 mL 11.2473 mL
5 mM 0.2249 mL 1.1247 mL 2.2495 mL
10 mM 0.1125 mL 0.5624 mL 1.1247 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (2.34 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (2.34 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (2.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Nanchangmycin
Cat. No.:
HY-100528
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