2. Metabolic Enzyme/Protease Anti-infection Apoptosis Autophagy
  3. Oxidative Phosphorylation Bacterial Fungal Apoptosis Autophagy Antibiotic
  4. Calcimycin hemicalcium salt

Calcimycin hemicalcium salt  (Synonyms: A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt)

Cat. No.: HY-N6687A
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Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy.

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CAS No. : 59450-89-4

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Calcimycin hemicalcium salt Related Antibodies

Top Publications Citing Use of Products

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873.  [Abstract]

    A23187 (5 µM; 1–6 h) induced apoptosis in microglia in vitro. Microglia viability was assessed using the CCK-8 assay.

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873.  [Abstract]

    A23187 (5 µM; 4 h). Representative images of microglia stained with Iba1, citH3, and MPO triple staining, and colocalization analysis of MPO, citH3, and DNA in the three cell groups.

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149.  [Abstract]

    Cells were treated with different concentrations of Calcimycin (A23187: 2 µmol/L, 4 µmol/L, 8 µmol/L, 10 µmol/L; 24 h), and the effect of A23187 on STAT1 expression was assessed by Western blotting.

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149.  [Abstract]

    Cells were treated with A23187 (4 µmol/L; 24 h) to examine the effect of A21187 on the binding ability of TRIM21 and STAT1 by Co‐IP and western blotting, and the result showed that A23187 reversed the dissociation of TRIM21 and STAT1 in the context of TGM2 and increased ubiquitination of STAT1.

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149.  [Abstract]

    The effect of A23187 (4 µmol/L; 0-96 h) and ZM39923 (20 nmol/L) on GC cell proliferation was evaluated by CCK8 assay. The result showed that ZM39923 promoted cell proliferation while A23187 had an inhibitory role in GC cell proliferation.

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    Description

    Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy[1][2][3][4][5].

    In Vitro

    Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Calcimycin hemicalcium salt Related Antibodies
    In Vivo

    Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice (ICR, 25-30 g)[5]
    Dosage: 2.5 or 7.5 nM
    Administration: Intrapleurally
    Result: Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
    Molecular Weight

    1085.30

    Formula

    C58H72CaN6O12
    CAS No.
    SMILES

    CNC1=CC=C2OC(C[C@@H]3[C@@H](CC[C@@]4(O3)[C@@H](C[C@H]([C@H](O4)[C@@H](C(C5=CC=CN5)=O)C)C)C)C)=NC2=C1C([O-][Ca+2][O-]C(C6=C7N=C(C[C@H]8O[C@]9(O[C@H]([C@H](C)C(C%10=CC=CN%10)=O)[C@H](C)C[C@H]9C)CC[C@H]8C)OC7=CC=C6NC)=O)=O
    Structure Classification
    Initial Source

    Streptomyces chartreusis
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Calcimycin hemicalcium salt Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Calcimycin hemicalcium59450-89-4A-23187 hemicalcium Antibiotic A-23187 hemicalciumOxidative PhosphorylationBacterialFungalApoptosisAutophagyAntibioticmycobacterialdivalentcationionophoreGram-positivebacteriaphosphorylationInhibitorinhibitorinhibit

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