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Calcimycin hemicalcium salt

(Synonyms: A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt)
26 Cited Publications
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Based on 26 publication(s) in Google Scholar

Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis and autophagy.

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  • CAS No.: 59450-89-4
  • Formula: C58H72CaN6O12
  • Molecular Weight:1085.30
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Calcimycin hemicalcium salt Chemical Structure
    Calcimycin hemicalcium salt Chemical Structure
  • Experimental Validation Results for Calcimycin hemicalcium salt
  • Experimental Validation Results for Calcimycin hemicalcium salt
  • Experimental Validation Results for Calcimycin hemicalcium salt
  • Experimental Validation Results for Calcimycin hemicalcium salt
  • Experimental Validation Results for Calcimycin hemicalcium salt
CAS No.: 59450-89-4
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  • Calcimycin hemicalcium salt Chemical Structure
    Calcimycin hemicalcium salt Chemical Structure
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    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873. [Abstract]

    Customer Validation
     A23187 (5 µM; 1–6 h) induced apoptosis in microglia in vitro. Microglia viability was assessed using the CCK-8 assay.

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    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873. [Abstract]

    Customer Validation
     A23187 (5 µM; 4 h). Representative images of microglia stained with Iba1, citH3, and MPO triple staining, and colocalization analysis of MPO, citH3, and DNA in the three cell groups.

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    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

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     Cells were treated with different concentrations of Calcimycin (A23187: 2 µmol/L, 4 µmol/L, 8 µmol/L, 10 µmol/L; 24 h), and the effect of A23187 on STAT1 expression was assessed by Western blotting.

  • 1/16

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

    Customer Validation
     Cells were treated with A23187 (4 µmol/L; 24 h) to examine the effect of A21187 on the binding ability of TRIM21 and STAT1 by Co‐IP and western blotting, and the result showed that A23187 reversed the dissociation of TRIM21 and STAT1 in the context of TGM2 and increased ubiquitination of STAT1.

  • 1/16

    Calcimycin hemicalcium salt purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

    Customer Validation
     The effect of A23187 (4 µmol/L; 0-96 h) and ZM39923 (20 nmol/L) on GC cell proliferation was evaluated by CCK8 assay. The result showed that ZM39923 promoted cell proliferation while A23187 had an inhibitory role in GC cell proliferation.

  • Calcimycin hemicalcium salt