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  3. Calcimycin hemicalcium salt

Calcimycin hemicalcium salt (Synonyms: A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt)

Cat. No.: HY-N6687A
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Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. Calcimycin hemicalcium salt induces apoptosis.

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Calcimycin hemicalcium salt Chemical Structure

Calcimycin hemicalcium salt Chemical Structure

CAS No. : 59450-89-4

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Description

Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation of mammalian cells. Calcimycin hemicalcium salt induces apoptosis[1][2][3][4].

In Vitro

Calcimycin hemicalcium salt (A-23187 calcium) mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

In Vivo

Calcimycin hemicalcium salt (A-23187 calcium) (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

Animal Model: Mice (ICR, 25-30 g)[5]
Dosage: 2.5 or 7.5 nM
Administration: Intrapleurally
Result: Two hours after 2.5 nM, or 3 hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
Molecular Weight

1085.30

Formula

C₅₈H₇₂CaN₆O₁₂

CAS No.

59450-89-4

SMILES

CNC1=CC=C2OC(C[[email protected]@H]3[[email protected]@H](CC[[email protected]@]4(O3)[[email protected]@H](C[[email protected]]([[email protected]](O4)[[email protected]@H](C(C5=CC=CN5)=O)C)C)C)C)=NC2=C1C([O-][Ca+2][O-]C(C6=C7N=C(C[[email protected]]8O[[email protected]]9(O[[email protected]]([[email protected]](C)C(C%10=CC=CN%10)=O)[[email protected]](C)C[[email protected]]9C)CC[[email protected]]8C)OC7=CC=C6NC)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Calcimycin hemicalciumA-23187 hemicalciumAntibiotic A-23187 hemicalciumBacterialFungalApoptosisAutophagymycobacterialdivalentcationionophoreGram-positivebacteriaphosphorylationInhibitorinhibitorinhibit

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Calcimycin hemicalcium salt
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