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  2. Bacterial
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  3. Calcimycin hemimagnesium

Calcimycin hemimagnesium (Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

Cat. No.: HY-N6687B
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Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis.

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Calcimycin hemimagnesium Chemical Structure

Calcimycin hemimagnesium Chemical Structure

CAS No. : 72124-77-7

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Description

Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis[1][2][3][4].

In Vitro

Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner[4].

In Vivo

Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage[5].

Animal Model: Mice (ICR, 25-30 g)[5]
Dosage: 2.5 or 7.5 nM
Administration: Intrapleurally
Result: Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.
Molecular Weight

1069.53

Formula

C₅₈H₇₂MgN₆O₁₂

CAS No.

72124-77-7

SMILES

CNC1=CC=C2OC(C[[email protected]@H]3[[email protected]@H](CC[[email protected]@]4(O3)[[email protected]@H](C[[email protected]]([[email protected]](O4)[[email protected]@H](C(C5=CC=CN5)=O)C)C)C)C)=NC2=C1C([O-][Mg+2][O-]C(C6=C7N=C(C[[email protected]]8O[[email protected]]9(O[[email protected]]([[email protected]](C)C(C%10=CC=CN%10)=O)[[email protected]](C)C[[email protected]]9C)CC[[email protected]]8C)OC7=CC=C6NC)=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Calcimycin hemimagnesiumA-23187 hemimagnesiumAntibiotic A-23187 hemimagnesiumBacterialFungalApoptosisAutophagymycobacterialdivalentcationionophoreGram-positivebacteriaphosphorylationInhibitorinhibitorinhibit

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Calcimycin hemimagnesium
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