2. Membrane Transporter/Ion Channel Neuronal Signaling TGF-beta/Smad Epigenetics Anti-infection Apoptosis
  3. Calcium Channel PKC Bacterial Apoptosis Antibiotic
  4. Ionomycin calcium

Ionomycin calcium  (Synonyms: SQ23377 calcium)

Cat. No.: HY-13434A Purity: ≥98.0%
COA Handling Instructions

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

Ionomycin calcium Chemical Structure

Ionomycin calcium Chemical Structure

CAS No. : 56092-82-1

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5 mg USD 390 In-stock
10 mg USD 525 In-stock
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Customer Review

Based on 38 publication(s) in Google Scholar

Other Forms of Ionomycin calcium:

Ionomycin calcium Related Antibodies

Top Publications Citing Use of Products

37 Publications Citing Use of MCE Ionomycin calcium

IF

    Ionomycin calcium purchased from MCE. Usage Cited in: J Ethnopharmacol. 2022 Dec 8;303:116031.  [Abstract]

    Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM ionomycin, respectively.

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    Description

    Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC)[1][2][3].

    IC50 & Target

    Calcium ionophore[1]
    In Vitro

    Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
    Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
    Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Ionomycin calcium Related Antibodies
    Clinical Trial
    Molecular Weight

    747.07

    Appearance

    Solid

    Formula

    C41H70CaO9
    CAS No.
    SMILES

    O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2]
    Structure Classification
    Initial Source

    Streptomyces conglobatus
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (66.93 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3386 mL 6.6928 mL 13.3856 mL
    5 mM 0.2677 mL 1.3386 mL 2.6771 mL
    10 mM 0.1339 mL 0.6693 mL 1.3386 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: ≥98.0%

    COA (244 KB)

    Handling Instructions (2659 KB)
    References
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    Ionomycin calcium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Keywords:

    Ionomycin56092-82-1SQ23377SQ 23377SQ-23377Calcium ChannelPKCBacterialApoptosisAntibioticCa2+ channelsCa channelsProtein kinase CcleavageexosomecalciumionophoreantibioticInhibitorinhibitorinhibit

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