1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. Calcium Channel
    PKC
    Apoptosis
  3. Ionomycin calcium

Ionomycin calcium (Synonyms: SQ23377 calcium)

Cat. No.: HY-13434A Purity: >98.0%
Handling Instructions

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC).

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Ionomycin calcium Chemical Structure

Ionomycin calcium Chemical Structure

CAS No. : 56092-82-1

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Description

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC)[1][2][3].

IC50 & Target

Calcium ionophore[1]

In Vitro

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1]. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].

Clinical Trial
Molecular Weight

747.07

Formula

C₄₁H₇₀CaO₉

CAS No.

56092-82-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (13.39 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3386 mL 6.6928 mL 13.3856 mL
5 mM 0.2677 mL 1.3386 mL 2.6771 mL
10 mM 0.1339 mL 0.6693 mL 1.3386 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >98.0%

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Keywords:

IonomycinSQ23377SQ 23377SQ-23377Calcium ChannelPKCApoptosisCa2+ channelsCa channelsProtein kinase CInhibitorinhibitorinhibit

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Ionomycin calcium
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