1. Membrane Transporter/Ion Channel Neuronal Signaling TGF-beta/Smad Epigenetics Anti-infection Apoptosis
  2. Calcium Channel PKC Bacterial Apoptosis Antibiotic
  3. Ionomycin calcium

Ionomycin calcium  (Synonyms: SQ23377 calcium)

Cat. No.: HY-13434A Purity: ≥98.0%
COA Handling Instructions

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

Ionomycin calcium Chemical Structure

Ionomycin calcium Chemical Structure

CAS No. : 56092-82-1

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1 mg USD 156 In-stock
5 mg USD 390 In-stock
10 mg USD 525 In-stock
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Customer Review

Based on 38 publication(s) in Google Scholar

Other Forms of Ionomycin calcium:

Top Publications Citing Use of Products

37 Publications Citing Use of MCE Ionomycin calcium

IF

    Ionomycin calcium purchased from MCE. Usage Cited in: J Ethnopharmacol. 2022 Dec 8;303:116031.  [Abstract]

    Calcium imaging in HEK293T cells expressing E649A, E652K, and E652D mutants responds to 10 nM capsaicin, the cocktail of 10 nM capsaicin and 30 μM s-RhTx, 10 μM capsaicin, and 10 μM ionomycin, respectively.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC)[1][2][3].

    IC50 & Target

    Calcium ionophore[1]

    In Vitro

    Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
    Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
    Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    747.07

    Appearance

    Solid

    Formula

    C41H70CaO9

    CAS No.
    SMILES

    O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2]

    Structure Classification
    Initial Source

    Streptomyces conglobatus

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (66.93 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3386 mL 6.6928 mL 13.3856 mL
    5 mM 0.2677 mL 1.3386 mL 2.6771 mL
    10 mM 0.1339 mL 0.6693 mL 1.3386 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (3.35 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: ≥98.0%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Ionomycin calcium
    Cat. No.:
    HY-13434A
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