1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Epigenetics
    TGF-beta/Smad
    Apoptosis
  2. Calcium Channel
    PKC
    Apoptosis
  3. Ionomycin calcium

Ionomycin calcium (Synonyms: SQ23377 calcium)

Cat. No.: HY-13434A
Handling Instructions

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC).

For research use only. We do not sell to patients.

Ionomycin calcium Chemical Structure

Ionomycin calcium Chemical Structure

CAS No. : 56092-82-1

Size Stock
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Ionomycin calcium:

Other Forms of Ionomycin calcium:

Top Publications Citing Use of Products

Publications Citing Use of MCE Ionomycin calcium

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC)[1][2][3].

IC50 & Target

Calcium ionophore[1]

In Vitro

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1]. Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].

Molecular Weight

747.07

Formula

C₄₁H₇₀CaO₉

CAS No.

56092-82-1

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ionomycin calcium
Cat. No.:
HY-13434A
Quantity:
MCE Japan Authorized Agent: