6601-66-7
Chemical Structure
6-Demethoxytangeretin
- CAS. Nr.: 6601-66-7
- Formula:C19H18O6
- Molecular Weight:342.34
IUPAC Name: 5,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
InChIKey: DDGJUTBQQURRGE-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=CC(OC)=C13
Biological Activity: 6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons[1][2].
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6-Demethoxytangeretin | 99.37% | 6-Demethoxytangeretin is a flavonoid compound that can be isolated from Citrus reticulata. 6-Demethoxytangeretin has anti-inflammatory and anti-allergic activities and can inhibit the production of IL-6 and the expression of related genes in human mast cells through the ALK and MAPK pathways. 6-Demethoxytangeretin can promote CRE-mediated transcription in hippocampal neurons. | ||||||||||||||||||||
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- [1]. Kim YM, et al. A citrus flavonoid, 6-demethoxytangeretin, suppresses production and gene expression of interleukin-6 in human mast cell-1 via anaplastic lymphoma kinase and mitogen-activated protein kinase pathways. Biol Pharm Bull. 2014;37(5):871-6. Epub 2014 Feb 5. [Content Brief]
- [2]. Kawahata I, et al. Potent activity of nobiletin-rich Citrus reticulata peel extract to facilitate cAMP/PKA/ERK/CREB signaling associated with learning and memory in cultured hippocampal neurons: identification of the substances responsible for the pharmacological action. J Neural Transm (Vienna). 2013 Oct;120(10):1397-409. [Content Brief]
Keywords
