1. Immunology/Inflammation
    Metabolic Enzyme/Protease
    Apoptosis
  2. COX
    Lipoxygenase
    Apoptosis
  3. Licofelone

Licofelone (Synonyms: ML-3000)

Cat. No.: HY-B1452 Purity: >99.0%
Handling Instructions

Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.

For research use only. We do not sell to patients.

Licofelone Chemical Structure

Licofelone Chemical Structure

CAS No. : 156897-06-2

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Description

Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2][3].

IC50 & Target

COX

0.21 μM (IC50)

5-LOX

0.18 μM (IC50)

In Vitro

The IC50s of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively[3].

Molecular Weight

379.88

Formula

C₂₃H₂₂ClNO₂

CAS No.

156897-06-2

SMILES

O=C(O)CC1=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)=C4N1CC(C)(C)C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (65.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6324 mL 13.1621 mL 26.3241 mL
5 mM 0.5265 mL 2.6324 mL 5.2648 mL
10 mM 0.2632 mL 1.3162 mL 2.6324 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

LicofeloneML-3000ML3000ML 3000COXLipoxygenaseApoptosisCyclooxygenaseLOXInhibitorinhibitorinhibit

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