1. Immunology/Inflammation
    Metabolic Enzyme/Protease
    Apoptosis
  2. COX
    Lipoxygenase
    Apoptosis
  3. Licofelone

Licofelone (Synonyms: ML-3000)

Cat. No.: HY-B1452 Purity: >99.0%
Handling Instructions

Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.

For research use only. We do not sell to patients.

Licofelone Chemical Structure

Licofelone Chemical Structure

CAS No. : 156897-06-2

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Estimated Time of Arrival: December 31
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Description

Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2][3].

IC50 & Target[3]

COX

0.21 μM (IC50)

5-LOX

0.18 μM (IC50)

In Vitro

The IC50s of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively[3].

Molecular Weight

379.88

Formula

C₂₃H₂₂ClNO₂

CAS No.

156897-06-2

SMILES

O=C(O)CC1=C(C2=CC=C(Cl)C=C2)C(C3=CC=CC=C3)=C4N1CC(C)(C)C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

LicofeloneML-3000ML3000ML 3000COXLipoxygenaseApoptosisCyclooxygenaseLOXInhibitorinhibitorinhibit

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