1. Immunology/Inflammation
  2. COX
  3. Aceclofenac

Aceclofenac 

Cat. No.: HY-B0634 Purity: 99.75%
Handling Instructions

Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.

For research use only. We do not sell to patients.

Aceclofenac Chemical Structure

Aceclofenac Chemical Structure

CAS No. : 89796-99-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 86 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All COX Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].

IC50 & Target[1]

COX-2

3 μM (IC50)

COX-1

7.3 μM (IC50)

In Vitro

Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes[1].
Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreased by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test[1].
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aceclofenac shows a half-life of 3.24 ± 0.83 h for rat (10 mg/kg, iv)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 32-340 g[3]
Dosage: 10 mg/kg for i.v., 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration: Oral administration, intravenous injection
Result: T1/2 (3.24 ± 0.83 h for i.v.; 1.92 h for p.o.), Cmax (4.59μg/mL for p.o.).
Clinical Trial
Molecular Weight

354.18

Formula

C₁₆H₁₃Cl₂NO₄

CAS No.

89796-99-6

SMILES

O=C(OCC(O)=O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.34 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.28 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8234 mL 14.1171 mL 28.2342 mL
5 mM 0.5647 mL 2.8234 mL 5.6468 mL
10 mM 0.2823 mL 1.4117 mL 2.8234 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AceclofenacCOXCyclooxygenaserheumatoidarthritisosteoarthritisankylosingspondylitiscytokineanalgesicanti-inflammatoryInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Aceclofenac
Cat. No.:
HY-B0634
Quantity:
MCE Japan Authorized Agent: