1. Immunology/Inflammation
  2. COX
  3. Aceclofenac

Aceclofenac 

Cat. No.: HY-B0634 Purity: 99.75%
Handling Instructions

Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis.

For research use only. We do not sell to patients.

Aceclofenac Chemical Structure

Aceclofenac Chemical Structure

CAS No. : 89796-99-6

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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5 g USD 86 In-stock
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Description

Aceclofenac is an orally active nonsteroidal anti-inflammatory drug (NSAID), with analgesic and anti-inflammatory properties. Aceclofenac is used for the research of osteoarthritis, ankylosing spondylitis, rheumatoid arthritis[1][2].

IC50 & Target[1]

COX-2

3 μM (IC50)

COX-1

7.3 μM (IC50)

In Vitro

Aceclofenac (1-30 μM; 72 hours) significantly decreases interleukin-6 production and fully blocks prostaglandin E2 synthesis by IL-1β- or LPS-stimulated human chondrocytes[1].
Aceclofenac inhibits COX-1 with IC50 values superior to 100 μM, but decreases by 50% COX-2 activity at the concentration of 0.77 μM in the whole blood test[1].
Aceclofenac increases the synthesis of interleukin 1 receptor antagonist and decreases the production of nitric oxide in human articular chondrocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aceclofenac exhibits Cmax (4.59 μg/mL) following oral administration (rat 20 mg/kg)[3].
Aceclofenac exhibits terminal elimination half-life (rat 3.24 h) due to high plasma clearance (rat 1.10 L/h/kg) following intravenous injection (rat 10 mg/kg)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats weighing 32-340 g[3]
Dosage: 10 mg/kg for i.v., 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration: Oral administration and intravenous injection
Result: T1/2 (3.24 h), Cmax (4.59 μg/mL for p.o.).
Clinical Trial
Molecular Weight

354.18

Formula

C₁₆H₁₃Cl₂NO₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (282.34 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.28 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8234 mL 14.1171 mL 28.2342 mL
5 mM 0.5647 mL 2.8234 mL 5.6468 mL
10 mM 0.2823 mL 1.4117 mL 2.8234 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Aceclofenac
Cat. No.:
HY-B0634
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