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  3. Tenuigenin

Tenuigenin (Synonyms: Senegenin)

Cat. No.: HY-N0802 Purity: 99.24%
Handling Instructions

Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.

For research use only. We do not sell to patients.

Tenuigenin Chemical Structure

Tenuigenin Chemical Structure

CAS No. : 2469-34-3

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5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
20 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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Description

Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1].

IC50 & Target[1]

NF-κB

 

In Vivo

Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice[1].

Molecular Weight

537.13

Formula

C₃₀H₄₅ClO₆

CAS No.

2469-34-3

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (186.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8617 mL 9.3087 mL 18.6175 mL
5 mM 0.3723 mL 1.8617 mL 3.7235 mL
10 mM 0.1862 mL 0.9309 mL 1.8617 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

TenuigeninSenegeninNF-κBNuclear factor-κBNuclear factor-kappaBPolygalatenuifoliaS.aureuspneumoniaanti-inflammatoryInhibitorinhibitorinhibit

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Tenuigenin
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