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  3. Tenuigenin

Tenuigenin (Synonyms: Senegenin)

Cat. No.: HY-N0802
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Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.

For research use only. We do not sell to patients.

Tenuigenin Chemical Structure

Tenuigenin Chemical Structure

CAS No. : 2469-34-3

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Description

Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect[1].

IC50 & Target

NF-κB

 

In Vivo

Tenuigenin (2, 4, 8 mg/kg) significantly attenuates S.aureus-induced lung histopathological changes. Tenuigenin also inhibits lung wet/dry (W/D) ratio, and inflammatory cytokines TNF-α and IL-1β production in Male BALB/c mice[1].

Molecular Weight

537.13

Formula

C₃₀H₄₅ClO₆

CAS No.

2469-34-3

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Keywords:

TenuigeninSenegeninNF-κBNuclear factor-κBNuclear factor-kappaBPolygalatenuifoliaS.aureuspneumoniaanti-inflammatoryInhibitorinhibitorinhibit

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