PSB-0788 

PSB-0788 is a new selective high-affinity A_2B antagonist with IC₅₀ value of 3.64 nM and K_i value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases^[1].

IC50: 3.64 nM (A_2BAdoR)^[1].
Ki: 0.393 nM (human, A_2B); >1000 nM (A3 human recombinant); 333 nM (A2A human recombinant); 1730 nM (A2A rat brain striatal membranes); 2240 nM (A1 human recombinant); 386 nM (A1 rat brain cortical membranes))^[1].

PSB-0788 (compound 17) has high potency at the A_2BAdoR with IC₅₀ value of 3.64 nM^[1].
PSB-0788 has good profile of affinity and selectivity (K_i: 0.393 nM (A2B human recombinant); >1000 nM (A3 human recombinant); 333 nM (A2A human recombinant); 1730 nM (A2A rat brain striatal membranes); 2240 nM (A1 human recombinant); 386 nM (A1 rat brain cortical membranes))^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

543.04

C₂₅H₂₇ClN₆O₄S

1027513-54-7

O=C1NC2=C(C(N1CCC)=O)NC(C3=CC=C(S(=O)(N4CCN(CC4)CC5=CC=C(C=C5)Cl)=O)C=C3)=N2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Thomas Borrmann, et al. 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J Med Chem. 2009 Jul 9;52(13):3994-4  [Content Brief]