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  3. Catalpol

Catalpol (Synonyms: Catalpinoside)

Cat. No.: HY-N0820 Purity: 98.04%
Handling Instructions

Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects.

For research use only. We do not sell to patients.

Catalpol Chemical Structure

Catalpol Chemical Structure

CAS No. : 2415-24-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

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Description

Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects[1][2][3].

In Vitro

Catalpol (0.1 μg/mL; for 3 days) can induce neuronal differentiation in PC12 cells through activation of the intracellular signal transduction pathway, and promote neurite length[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Catalpol (25-100 mg/kg; intraperitoneal injection; once) treatment clearly reduces blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal ischemia/reperfusion-injury (IRI) mice. Catalpol markedly reduces the expression of PI3K, Akt and eNOS levels, and suppresses the TNF-α, IL-1β, IL-6 and IL-10 activities[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice treated with renal ischemia/reperfusion surgery[1]
Dosage: 25 mg/kg, 50 mg/kg and 100 mg/kg
Administration: Intraperitoneal injection; once
Result: Clearly reduced blood urea nitrogen, serum creatinine levels and the expression of KIM-1 in renal IRI mice.
Molecular Weight

362.33

Formula

C₁₅H₂₂O₁₀

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (82.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7599 mL 13.7996 mL 27.5992 mL
5 mM 0.5520 mL 2.7599 mL 5.5198 mL
10 mM 0.2760 mL 1.3800 mL 2.7599 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.04%

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Keywords:

CatalpolCatalpinosideHBVHepatitis B virusanti-cancerneuroprotectiveanti-inflammatorydiuretichypoglycemichepatitisvirusiridoidglycosideInhibitorinhibitorinhibit

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Catalpol
Cat. No.:
HY-N0820
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