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Aucubin 

Cat. No.: HY-N0664 Purity: 98.36%
Handling Instructions

Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects.

For research use only. We do not sell to patients.

Aucubin Chemical Structure

Aucubin Chemical Structure

CAS No. : 479-98-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 77 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg USD 230 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects[1][2][3].

In Vitro

Aucubin (0.001-1 μg/mL; pretreated for 30 min) dose-dependently inhibits IgE-induced TNF-α and IL-6 production and expression in RBL-2H3 cells, with IC50s of 0.101 and 0.19 μg/mL, respectively[2].
Aucubin (0.01 μg/mL; pretreated for 30 min) inhibits IgE-induced nuclear translocation of p65 subunit of NF-κB and degradation of IκBα in RBL-2H3 cells[2].
Aucubin (0.001-1 mM; 12 h) increases PC12 cellular viability and markedly inhbits H2O2-induced apoptotic cell death[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Aucubin (5 mg/kg; i.p. for 15 d) has antioxidant and pancreas-protective effects on rats with streptozotocin-induced diabetes[1].
Aucubin (40-200 mg/kg; a single i.p.) exhibits significant protective activity against α-amanitin intoxication in mice[5].
Aucubin (5 mg/kg/day; i.p. for 21 d) decreases the breathing frequency, increases the lung dynamic compliance, alleviates lung parenchymal fibrotic changes, and reduces the intrapulmonary collagen disposition and inflammatory injury of BLM-stimulated mice[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (200-230 g) induced diabetes by a injection of streptozotocin[1]
Dosage: 5 mg/kg
Administration: I.p. twice daily for the first 5 days, followed by single injections daily for the last 10 days
Result: Increased the body weight of streptozotocin-diabetic rats.
Lowered the blood glucose level.
Decreased the level of lipid peroxidation and increased the activities of antioxidant enzymes.
Increased in insulin immunoreactivity and the number of immunoreactive β cells compared with untreated diabetic rats.
Molecular Weight

346.33

Formula

C₁₅H₂₂O₉

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (288.74 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8874 mL 14.4371 mL 28.8742 mL
5 mM 0.5775 mL 2.8874 mL 5.7748 mL
10 mM 0.2887 mL 1.4437 mL 2.8874 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.5 mg/mL (7.22 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References

Purity: 98.36%

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Keywords:

AucubinBacterialiridoidglucosidePlantagoasiaticaEucommiaulmoidesantioxidantaginginflammatoryantimicrobialanti-fibroticcancerhepatoprotectiveneuroprotectiveosteoprotectiveInhibitorinhibitorinhibit

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Aucubin
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