2. Apoptosis
  3. Ferroptosis Apoptosis
  4. Gastrodin

Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H2O2-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia.

For research use only. We do not sell to patients.

CAS No. : 62499-27-8

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 18 publication(s) in Google Scholar

Other Forms of Gastrodin:

Gastrodin Related Antibodies

Top Publications Citing Use of Products

    Gastrodin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):496.  [Abstract]

    Virus titer detection of BPIV3, VSV, and HSV-1 determined by TCID50 after challenge with DMSO (vehicle control) and Cedrelone (1 μM), and Gastrodin (GTD, 50 μM) serves as a positive control.

    Gastrodin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):496.  [Abstract]

    Real-time PCR analysis of the viral gene expression in BPIV3 infected MDBK cells and VSV or HSV-1 infected HeLa cells after challenge with DMSO, Cedrelone (1 μM) and Gastrodin (50 μM).

    Gastrodin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):496.  [Abstract]

    Western blotting analysis of the viral protein expression in BPIV3 infected MDBK cells and VSV or HSV-1 infected HeLa cells after challenge with DMSO, Cedrelone (1 μM) and Gastrodin (50 μM).

    Gastrodin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:429-442.  [Abstract]

    Gastrodin mitigates high fructose-induced sweet taste preference decline and hippocampal NSC reduction in mice. Mice were divided into groups receiving either a standard diet or a diet containing 60 % fructose for 12 weeks. Within the fructose groups, five subgroups were formed: Gastrodin treatment (50, 100, and 200 mg/kg) and Pioglitazone treatment (30 mg/kg) for 8 weeks, 60 % fructose diet without additional treatment. Body weight of mice was shown in the final week (age: 18-week-old) after fructose feeding and/or gastrodin treatment.SPT was performed to detect sweet taste preference in mice.

    Gastrodin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:429-442.  [Abstract]

    Representative confocal image labeled with BODIPY was shown in primary NSCs treated with or without Gastrodin (20, 40, and 80 μmol/L) and Pioglitazone (10 μmol/L). The relative BODIPYOX fluorescence intensity was shown on the right.

    Gastrodin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:429-442.  [Abstract]

    Western blotting was used to detect ZIC2 and CISD1 protein levels in primary NSCs stimulated with or without Gastrodin (20, 40, and 80 μmol/L) and Pioglitazone (10 μmol/L), and densitometry analysis of bands was quantized as shown.

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H2O2-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia[1][2][3].

    In Vitro

    Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Gastrodin Related Antibodies
    In Vivo

    Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    286.28

    Formula

    C13H18O7
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (349.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 100 mg/mL (349.31 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4931 mL 17.4654 mL 34.9308 mL
    5 mM 0.6986 mL 3.4931 mL 6.9862 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (349.31 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References
    Cell Assay
    [1]

    Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [1]

    Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.4931 mL 17.4654 mL 34.9308 mL 87.3271 mL
    5 mM 0.6986 mL 3.4931 mL 6.9862 mL 17.4654 mL
    10 mM 0.3493 mL 1.7465 mL 3.4931 mL 8.7327 mL
    15 mM 0.2329 mL 1.1644 mL 2.3287 mL 5.8218 mL
    20 mM 0.1747 mL 0.8733 mL 1.7465 mL 4.3664 mL
    25 mM 0.1397 mL 0.6986 mL 1.3972 mL 3.4931 mL
    30 mM 0.1164 mL 0.5822 mL 1.1644 mL 2.9109 mL
    40 mM 0.0873 mL 0.4366 mL 0.8733 mL 2.1832 mL
    50 mM 0.0699 mL 0.3493 mL 0.6986 mL 1.7465 mL
    60 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4555 mL
    80 mM 0.0437 mL 0.2183 mL 0.4366 mL 1.0916 mL
    100 mM 0.0349 mL 0.1747 mL 0.3493 mL 0.8733 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Gastrodin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Gastrodin62499-27-8GastrodineFerroptosisApoptosisInhibitorinhibitorinhibit

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