Cat. No.: HY-N0115

Gastrodin

(Synonyms: Gastrodine)

18 Cited Publications

Customer Review

Based on 18 publication(s) in Google Scholar

Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin inhibits ethanol-induced hepatocellular apoptosis. Gastrodin inhibits H₂O₂-induced ferroptosis through its antioxidative effect. Gastrodin can be used for study of dizziness, epilepsy, stroke and dementia.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 62499-27-8
Formula: C₁₃H₁₈O₇
Molecular Weight:286.28

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Gastrodin Chemical Structure

CAS No.: 62499-27-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (18)
Solvent & Solubility
- In Vitro
- In Vivo
Protocol
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm² and 201.9±43.1 cells/mm² in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 62499-27-8
Appearance Solid
Molecular Weight 286.28
Formula C₁₃H₁₈O₇
Color White to off-white
SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2
Synonyms

Gastrodine
Structure Classification
- Phenols
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (18)

All Microbiological AssayIn Vivo Efficacy StudyRT-PCRCell Imaging/StainingWB

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Journal Impact Factor

Nat Commun

Phenazine biosynthesis-like domain-containing protein (PBLD) and Cedrelone promote antiviral immune response by activating NF-ĸB. [Abstract]

2025 Jan 8;16(1):496. PMID: 39779683

Gastrodin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):496. [Abstract]

Virus titer detection of BPIV3, VSV, and HSV-1 determined by TCID₅₀ after challenge with DMSO (vehicle control) and Cedrelone (1 μM), and Gastrodin (GTD, 50 μM) serves as a positive control.

Gastrodin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):496. [Abstract]

Real-time PCR analysis of the viral gene expression in BPIV3 infected MDBK cells and VSV or HSV-1 infected HeLa cells after challenge with DMSO, Cedrelone (1 μM) and Gastrodin (50 μM).

Gastrodin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 8;16(1):496. [Abstract]

Western blotting analysis of the viral protein expression in BPIV3 infected MDBK cells and VSV or HSV-1 infected HeLa cells after challenge with DMSO, Cedrelone (1 μM) and Gastrodin (50 μM).
Acta Pharm Sin B

An injectable bioactive dressing based on platelet-rich plasma and nanoclay: Sustained release of deferoxamine to accelerate chronic wound healing. [Abstract]

2023 Oct;13(10):4318-4336. PMID: 37799395
J Adv Res

Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis. [Abstract]

2025 Aug:74:429-442. PMID: 39353531

Gastrodin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:429-442. [Abstract]

Gastrodin mitigates high fructose-induced sweet taste preference decline and hippocampal NSC reduction in mice. Mice were divided into groups receiving either a standard diet or a diet containing 60 % fructose for 12 weeks. Within the fructose groups, five subgroups were formed: Gastrodin treatment (50, 100, and 200 mg/kg) and Pioglitazone treatment (30 mg/kg) for 8 weeks, 60 % fructose diet without additional treatment. Body weight of mice was shown in the final week (age: 18-week-old) after fructose feeding and/or gastrodin treatment.SPT was performed to detect sweet taste preference in mice.

Gastrodin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:429-442. [Abstract]

Representative confocal image labeled with BODIPY was shown in primary NSCs treated with or without Gastrodin (20, 40, and 80 μmol/L) and Pioglitazone (10 μmol/L). The relative BODIPY^OX fluorescence intensity was shown on the right.

Gastrodin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Aug:74:429-442. [Abstract]

Western blotting was used to detect ZIC2 and CISD1 protein levels in primary NSCs stimulated with or without Gastrodin (20, 40, and 80 μmol/L) and Pioglitazone (10 μmol/L), and densitometry analysis of bands was quantized as shown.
Acta Pharmacol Sin

Gastrodin promotes CNS myelinogenesis and alleviates demyelinating injury by activating the PI3K/AKT/mTOR signaling. [Abstract]

2025 Jun;46(6):1610-1623. PMID: 40011630
Phytomedicine

Unraveling the neuroprotective mechanism of gastrodin against CRS-induced depression in adult male mice via Notch3: Integration of proteomics, transcriptomics, molecular docking, and cellular validation. [Abstract]

2025 Dec 12:150:157705. PMID: 41421276
Phytother Res

Gastrodin Ameliorates Tau Pathology and BBB Dysfunction in 3xTg-AD Transgenic Mice by Regulating the ADRA1/NF-κB/NLRP3 Pathway to Reduce Neuroinflammation. [Abstract]

2025 May;39(5):1996-2016. PMID: 39963073
Foods

Gastrodin Alleviates DSS-Induced Colitis in Mice through Strengthening Intestinal Barrier and Modulating Gut Microbiota. [Abstract]

2024 Aug 3;13(15):2460. PMID: 39123651
Eur J Pharmacol

Gastrodin alleviates perioperative neurocognitive dysfunction of aged mice by suppressing neuroinflammation. [Abstract]

2021 Feb 5;892:173734. PMID: 33220272
Molecules

Gastrodin Induces Ferroptosis of Glioma Cells via Upregulation of Homeobox D10. [Abstract]

2023 Dec 13;28(24):8062. PMID: 38138552
Sci Rep

Gastrodia protects HT22 cells from damage caused by oxygen glucose deprivation and reperfusion through inhibiting ferroptosis. [Abstract]

2025 May 27;15(1):18470. PMID: 40425648
Immunopharmacol Immunotoxicol

Gastrodin ameliorates Concanavalin A-induced acute hepatitis via the IL6/JAK2/STAT3 pathway. [Abstract]

2022 Dec;44(6):925-934. PMID: 35881007
Brain Res

Gastrodin ameliorates postoperative cognitive dysfunction in aged mice by promoting nuclear translocation of Nrf2 through activation of AMPK. [Abstract]

2024 Jan 1:1822:148607. PMID: 37806469
Tissue Cell

Gastrodin promotes ferroptosis in CRC cells by inhibiting SKP2 to reduce NCOA4 ubiquitination. [Abstract]

2025 Aug:95:102793. PMID: 40048831
Exp Ther Med

Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms. [Abstract]

2021 May;21(5):471. PMID: 33767766
Biochem Biophys Rep

Gastrodin alleviates myocardial infarction by inhibiting inflammation, and apoptosis and promoting endothelial cell proliferation. [Abstract]

2025 Apr 18:42:102014. PMID: 40290804
J Mol Histol

Gastrodin ameliorates diabetic nephropathy by activating the AMPK/Nrf2 pathway. [Abstract]

2024 Dec;55(6):1327-1339. PMID: 39520653
Otol Neurotol

Protective Effects of Gastrodin Against Gentamicin-Induced Vestibular Damage by the Notch Signaling Pathway. [Abstract]

2024 Oct 1;45(9):1059-1067. PMID: 39264922
Urol Int

Gastrodin Pretreatment Alleviates Renal Ischemia-Reperfusion Injury. [Abstract]

2022;106(6):630-637. PMID: 35051947

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (349.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (349.31 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4931 mL

17.4654 mL

34.9308 mL

5 mM

0.6986 mL

3.4931 mL

6.9862 mL

10 mM

0.3493 mL

1.7465 mL

3.4931 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (349.31 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Protocol

Cell Assay^[1]

Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[1]

Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489. [Content Brief]

[2]. Jiang T, Chu J, Chen H, et al. Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6. Biol Pharm Bull. 2020;43(3):480-487. [Content Brief]

[3]. Zhang Y, et al. Gastrodin Protects against Ethanol-Induced Liver Injury and Apoptosis in HepG2 Cells and Animal Models of Alcoholic Liver Disease. Biol Pharm Bull. 2018;41(5):670-679. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.4931 mL	17.4654 mL	34.9308 mL	87.3271 mL
	5 mM	0.6986 mL	3.4931 mL	6.9862 mL	17.4654 mL
	10 mM	0.3493 mL	1.7465 mL	3.4931 mL	8.7327 mL
	15 mM	0.2329 mL	1.1644 mL	2.3287 mL	5.8218 mL
	20 mM	0.1747 mL	0.8733 mL	1.7465 mL	4.3664 mL
	25 mM	0.1397 mL	0.6986 mL	1.3972 mL	3.4931 mL
	30 mM	0.1164 mL	0.5822 mL	1.1644 mL	2.9109 mL
	40 mM	0.0873 mL	0.4366 mL	0.8733 mL	2.1832 mL
	50 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.7465 mL
	60 mM	0.0582 mL	0.2911 mL	0.5822 mL	1.4555 mL
	80 mM	0.0437 mL	0.2183 mL	0.4366 mL	1.0916 mL
	100 mM	0.0349 mL	0.1747 mL	0.3493 mL	0.8733 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gastrodin

Apoptosis Compound Library

Immunology/Inflammation Compound Library

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Publications Citing Use of MedChemExpress (MCE) Gastrodin

Biological Activity

Chemical Information

Publications (18)

Solvent & Solubility

Protocol

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Gastrodin Related Classifications

Cat. No.: HY-N0115