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  3. Engeletin

Engeletin 

Cat. No.: HY-N0436 Purity: 99.72%
Handling Instructions

Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

For research use only. We do not sell to patients.

Engeletin Chemical Structure

Engeletin Chemical Structure

CAS No. : 572-31-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Engeletin purchased from MCE. Usage Cited in: J Inflamm Res. 2021 Mar 9;14:745-760.

    Chondrocytes are pretreated with Engeletin (10 μM and 20 μM) for two hours, and then TNF-α (20 ng/mL) is added to the culture medium and incubated for another 24 hours. The protein expression levels of collagen II, aggrecan, MMP9 and MMP3 are determined by Western blotting.

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    Description

    Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

    IC50 & Target[1]

    NF-κB

     

    In Vitro

    Engeletin is a flavanonol glycoside isolated from hymenaea martiana, inhibits NF-κB signaling-pathway activation[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Engeletin (25, 50, 100 mg/kg, i.p.) markedly reduces LPS-increased myeloperoxidase activity in mice, activates NF-κB-pathway activation, decreases the production of inflammatory mediators (iNOS and COX-2), and suppresses the expression of TLR4-signaling downstream molecules such as MyD88, IRAK1, TRAF6, and TAK1 proteins[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Molecular Weight

    434.39

    Formula

    C₂₁H₂₂O₁₀

    CAS No.

    572-31-6

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (230.21 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.3021 mL 11.5104 mL 23.0208 mL
    5 mM 0.4604 mL 2.3021 mL 4.6042 mL
    10 mM 0.2302 mL 1.1510 mL 2.3021 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [1]

    Mice[1]
    The mice are classified at random into the following six groups of 10 mice each to cause the endometritis model: blank group, LPS group, Engeletin (25, 50, and 100 mg/kg) + LPS groups, and Engeletin (100 mg/kg) group. Engeletin is solubilized by heated normal saline to give the final concentrations of 25, 50, and 100 mg/kg. Briefly, each uterus is infused with 50 μL of LPS (1 mg/mL) to induce endometritis. At 24 h after the instillation, Engeletin groups receive an intraperitoneal injection of diverse Engeletin concentrations (25, 50, and 100 mg/kg) three times (once every 6 h). The Engeletin group is given an intraperitoneal injection of Engeletin (100 mg/kg). The blank group receive the normal saline. Afterward, the mice are killed by CO2 inhalation. Uterus tissues are harvested and kept in −80°C[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.72%

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    Keywords:

    EngeletinNF-κBNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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