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Epirubicin hydrochloride

(Synonyms: 4'-Epidoxorubicin hydrochloride)
38 Cited Publications
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Based on 38 publication(s) in Google Scholar

Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin hydrochloride inhibits DNA and RNA synthesis. Epirubicin hydrochloride is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.

For research use only. We do not sell to patients.

  • Purity: 99.62%
  • CAS No.: 56390-09-1
  • Formula: C27H30ClNO11
  • Molecular Weight:579.98
  • Storage:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

  • Epirubicin hydrochloride Chemical Structure
    Epirubicin hydrochloride Chemical Structure
  • Experimental Validation Results for Epirubicin hydrochloride
  • Experimental Validation Results for Epirubicin hydrochloride
  • Experimental Validation Results for Epirubicin hydrochloride
  • Experimental Validation Results for Epirubicin hydrochloride
  • Experimental Validation Results for Epirubicin hydrochloride
  • Experimental Validation Results for Epirubicin hydrochloride
  • Experimental Validation Results for Epirubicin hydrochloride
CAS No.: 56390-09-1
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Proliferation/Viability AssayIn Vivo Efficacy StudyWB
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All DNA/RNA Synthesis Isoforms

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All Topoisomerase Isoforms

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  • Epirubicin hydrochloride Chemical Structure
    Epirubicin hydrochloride Chemical Structure
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    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2023 Jan;20(1):51-64. [Abstract]

    Customer Validation
     Comparison of drug (Epirubicin hydrochloride, EPI; Daunorubicin hydrochloride, DNR; Vinorelbine ditartrate, VNR; Oxaliplatin, OXA; Vincristine, VCR; Artemisinin, ART; Colchicine, COL) cytotoxicity to TC1 cells at the indicated doses and time points measured with CCK-8 assays. R.U. (Relative unit) was calculated from the average O.D. values in each condition as the indicator of cell viability (n = 3).

  • 1/16

    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Asia Pac J Clin Oncol. 2023 Jun;19(3):355-364. [Abstract]

    Customer Validation
     The Epirubicin (EPI) + iodine-125 (125I) group is significantly decreases the proliferation ability of HepG2 and SMMC7721 cells (cells are cultured for 2-3 weeks).

  • 1/16

    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Asia Pac J Clin Oncol. 2023 Jun;19(3):355-364. [Abstract]

    Customer Validation
     Epirubicin (EPI) promotes iodine-125 (125I)-induced downregulation of the WNT pathway and enhances the radiosensitivity of HepG2 and SMMC7721 cells.

  • 1/16

    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Apr 7;82(7):1297-1312.e8. [Abstract]

    Customer Validation
     CCK8 assay to detect the survival of MCF7 cells transfected with indicated siRNAs and treated with 1 μM EPI (Epirubicin hydrochloride; for 24 h).

  • 1/16

    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Apr 7;82(7):1297-1312.e8. [Abstract]

    Customer Validation
     CCK8 assay to detect the survival of MCF7 cells transfected with indicated siRNAs and treated with 1 μM EPI (Epirubicin hydrochloride; left) for 24 h or 0.5 μM EPI for 0-60 h (right).

  • 1/16

    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Apr 7;82(7):1297-1312.e8. [Abstract]

    Customer Validation
     Indicated MCF7 cells were treated with 1 μM EPI (Epirubicin hydrochloride) for 24 h. The levels of γH2AX were analyzed by immunoblotting (IB). Numbers represent its relative intensities measured by ImageJ.

  • 1/16

    Epirubicin hydrochloride purchased from MedChemExpress. Usage Cited in: Mol Cell. 2022 Apr 7;82(7):1297-1312.e8. [Abstract]

    Customer Validation
     Xenograft assay of lnc15.2-depleted and FL/FL∗-supplemented MDA-MB-231 cells (n = 5 per group). Tumor growth are shown. The arrow indicates each EPI (Epirubicin hydrochloride; 5 mg/Kg; i.p. on days 0, 4, 8 or 9) treatment.

  • Epirubicin hydrochloride