Taurochenodeoxycholic acid-d5 sodium
Based on 1 Customer Validation
Taurochenodeoxycholic acid-d5 (sodium) is the deuterium labeled Taurochenodeoxycholic acid sodium. Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.
For research use only. We do not sell to patients.
- Purity: 97.94%
- Formula: C26H39D5NNaO6S
- Molecular Weight:526.72
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 6009-98-9
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Appearance Solid
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Molecular Weight 526.72
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Formula C26H39D5NNaO6S
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Color White to off-white
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SMILES
C[C@]12[C@]([H])([C@]3([C@@]([H])([C@]4(C)[C@]([H])(C[C@H]3O)C([2H])([C@]([2H])(O)C([2H])(C4)[2H])[2H])CC2)[H])CC[C@@]1([C@@H](CCC(NCCS(=O)(O[Na])=O)=O)C)[H]
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Synonyms
12-Deoxycholyltaurine-d5 sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (189.85 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Wang X, et al. Taurochenodeoxycholic acid induces NR8383 cells apoptosis via PKC/JNK-dependent pathway. Eur J Pharmacol. 2016 Sep 5;786:109-15. [Content Brief]
[3]. Zhou C, et al. The effects of taurochenodeoxycholic acid in preventing pulmonary fibrosis in mice. Pak J Pharm Sci. 2013 Jul;26(4):761-5. [Content Brief]
[4]. Uchida A, et al. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation. Am J Physiol. 1997 May;272(5 Pt 1):G1249-57. [Content Brief]
[5]. Liu M, et al. Effects of taurochenodeoxycholic acid on adjuvant arthritis in rats. Int Immunopharmacol. 2011 Dec;11(12):2150-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8985 mL | 9.4927 mL | 18.9854 mL | 47.4636 mL |
| 5 mM | 0.3797 mL | 1.8985 mL | 3.7971 mL | 9.4927 mL | |
| 10 mM | 0.1899 mL | 0.9493 mL | 1.8985 mL | 4.7464 mL | |
| 15 mM | 0.1266 mL | 0.6328 mL | 1.2657 mL | 3.1642 mL | |
| 20 mM | 0.0949 mL | 0.4746 mL | 0.9493 mL | 2.3732 mL | |
| 25 mM | 0.0759 mL | 0.3797 mL | 0.7594 mL | 1.8985 mL | |
| 30 mM | 0.0633 mL | 0.3164 mL | 0.6328 mL | 1.5821 mL | |
| 40 mM | 0.0475 mL | 0.2373 mL | 0.4746 mL | 1.1866 mL | |
| 50 mM | 0.0380 mL | 0.1899 mL | 0.3797 mL | 0.9493 mL | |
| 60 mM | 0.0316 mL | 0.1582 mL | 0.3164 mL | 0.7911 mL | |
| 80 mM | 0.0237 mL | 0.1187 mL | 0.2373 mL | 0.5933 mL | |
| 100 mM | 0.0190 mL | 0.0949 mL | 0.1899 mL | 0.4746 mL |
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