1. Immunology/Inflammation
  2. PGE synthase
  3. Pranoprofen

Pranoprofen 

Cat. No.: HY-B0336 Purity: 98.48%
Handling Instructions

Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology.

For research use only. We do not sell to patients.

Pranoprofen Chemical Structure

Pranoprofen Chemical Structure

CAS No. : 52549-17-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 340 In-stock
Estimated Time of Arrival: December 31
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Description

Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology. Target: PGE2 Pranoprofen 0.1% was found to be as effective as diclofenac sodium 0.1% in reducing inflammation and pain after strabismus surgery. Pranoprofen could be used as a safe and effective anti-inflammatory alternative for the treatment of inflammation following strabismus surgery [1]. pranoprofen has efficacy equivalent to a moderate-potency corticosteroid with a better safety profile. It should be considered for the treatment of chronic conjunctivitis of presumed nonbacterial origin [2]. Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon. Moreover, pranoprofen inhibited ER stress-induced CCAAT/enhancer-binding protein homologous protein (CHOP) expression, an apoptotic transcription factor. the inhibitory effect of pranoprofen on ER stress-related genes (GRP78 and CHOP) would be mediated through the inhibition of XBP-1 splicing [3].

Clinical Trial
Molecular Weight

255.27

Formula

C₁₅H₁₃NO₃

CAS No.

52549-17-4

SMILES

CC(C(O)=O)C1=CC2=C(C=C1)OC3=NC=CC=C3C2

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (391.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9174 mL 19.5871 mL 39.1742 mL
5 mM 0.7835 mL 3.9174 mL 7.8348 mL
10 mM 0.3917 mL 1.9587 mL 3.9174 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Pranoprofen
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HY-B0336
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