1. Apoptosis
    Immunology/Inflammation
  2. COX
    Apoptosis
    PGE synthase
  3. Pranoprofen

Pranoprofen 

Cat. No.: HY-B0336 Purity: 98.48%
Handling Instructions

Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis.

For research use only. We do not sell to patients.

Pranoprofen Chemical Structure

Pranoprofen Chemical Structure

CAS No. : 52549-17-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 340 In-stock
Estimated Time of Arrival: December 31
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Description

Pranoprofen is a non-steroidal anti-inflammatory agent (NSAID) for the research of keratitis or other ophthalmology diseases. Pranoprofen inhibit COX-1 and COX-2 enzymes, thus blocking arachidonic acid converted to eicosanoids and reducing prostaglandins synthesis[1][2].

IC50 & Target[2]

COX-1

 

COX-2

 

In Vitro

Pranoprofen (pretreatment for 1 h; 1 mM) has an inhibitory effect against ER stress-induced GRP78 and CHOP expression in glial cells[1].
Pranoprofen (5-25 µM; 24 h) dose-dependently enhances Dicer expression. Additionally, Pranoprofen at 5 µM enhances H2O2 (800 µM)-induced Dicer expression in FHC cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pranoprofen (oral administration; 4 mg/kg/16 mg/kg; 9 days) rescues Dicer expression in inflamed colon tissues, alleviates colitis and prevents colitis-associated colon cancers in C57BL/6 mice[3].
Dicer is a key component of the RNA interference pathway and is essential for the biogenesis of miRNAs and siRNAs.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS-induced acute colitis in C57BL/6 mice[3]
Dosage: 4 mg/kg;16 mg/kg
Administration: Oral administration; 4 mg/kg/16 mg/kg; 9 days
Result: Alleviated inflammation in DSS-induced acute colitis.
Clinical Trial
Molecular Weight

255.27

Formula

C₁₅H₁₃NO₃

CAS No.

52549-17-4

SMILES

CC(C(O)=O)C1=CC2=C(C=C1)OC3=NC=CC=C3C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (391.74 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9174 mL 19.5871 mL 39.1742 mL
5 mM 0.7835 mL 3.9174 mL 7.8348 mL
10 mM 0.3917 mL 1.9587 mL 3.9174 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PranoprofenCOXApoptosisPGE synthaseCyclooxygenaseProstaglandin E synthaseNSAIDER stressdiseaseophthalmologykeratitispaincolon cancerprostaglandinInhibitorinhibitorinhibit

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Pranoprofen
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