1. Apoptosis
  2. RIP kinase
  3. RIPK3-IN-1

RIPK3-IN-1 

Cat. No.: HY-131064
Handling Instructions

RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM.

For research use only. We do not sell to patients.

RIPK3-IN-1 Chemical Structure

RIPK3-IN-1 Chemical Structure

CAS No. : 2361139-70-8

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Description

RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM[1].

IC50 & Target

IC50: 9.1 nM (RIPK3), 5.5 μM (RIPK1), >10 μM (RIPK2)[1]

In Vitro

RIPK3-IN-1 (Compound 18) also inhibits ABL, BRAF/V599E, MAP4K3, and SRC with IC50s of 0.37, 0.15, 0.012, and 0.075 μM, respectively[1].
Necroptosis is a programmed form of cell death and has been associated with a variety of diseases, including ischemia reperfusion injury, neurodegenerative disorders, pancreatic cancer, and autoimmune diseases such as inflammatory bowel disease (IBD). Upon stimulation of death receptors (such as the family of TNF receptors), signaling can initiate a necroptotic cell death process. This involves formation of a necrosome, which includes receptor interacting protein kinases 1 and 3 (RIPK1, RIPK3) in a cytosolic complex[1].

Molecular Weight

512.53

Formula

C₂₉H₂₅FN₄O₄

CAS No.

2361139-70-8

SMILES

O=C(C1=CC=CN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=C4)C(C)=C3C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

RIPK3-IN-1RIP kinaseReceptor-interacting protein kinasesRIPKRIPK3DFG-outNecroptosisinflammatoryboweldiseaseIBDInhibitorinhibitorinhibit

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HY-131064
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