1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. nAChR
  3. N-Methylcytisine

N-Methylcytisine  (Synonyms: Caulophylline)

Cat. No.: HY-N0443 Purity: 99.81%
COA Handling Instructions

N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia.

For research use only. We do not sell to patients.

N-Methylcytisine Chemical Structure

N-Methylcytisine Chemical Structure

CAS No. : 486-86-2

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 169 In-stock
Solution
10 mM * 1 mL in DMSO USD 169 In-stock
Solid
1 mg USD 75 In-stock
5 mg USD 158 In-stock
10 mg USD 269 In-stock
20 mg USD 457 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N-Methylcytisine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-Methylcytisine (Caulophylline), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[1][2].

IC50 & Target

kd: 50 nM (nicotinic acetylcholine receptors)[2]

Molecular Weight

204.27

Formula

C12H16N2O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=CC=C2N1C[C@]3([H])CN(C)C[C@@]2([H])C3

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (587.46 mM; Need ultrasonic)

H2O : 100 mg/mL (489.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8955 mL 24.4774 mL 48.9548 mL
5 mM 0.9791 mL 4.8955 mL 9.7910 mL
10 mM 0.4895 mL 2.4477 mL 4.8955 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (10.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (10.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (10.18 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.81%

References
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N-Methylcytisine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
N-Methylcytisine
Cat. No.:
HY-N0443
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