1. Anti-infection
    Metabolic Enzyme/Protease
  2. Parasite
    Phosphatase
    Influenza Virus
  3. Azadirachtin B

Azadirachtin B 

Cat. No.: HY-133108
Handling Instructions

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties.

For research use only. We do not sell to patients.

Azadirachtin B Chemical Structure

Azadirachtin B Chemical Structure

CAS No. : 106500-25-8

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Description

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties[1][2][3].

IC50 & Target

Plutella xylostella[1]
Alkaline phosphatase (ALP)[2]
Epstein-Barr virus early antigen (EBV-EA)[3]

In Vitro

Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells[1].
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control[1].
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 µg/g body weight, in 92 h[2].
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA)[3].

Cell Proliferation Assay[1]

Cell Line: Osteoblast cells
Concentration: 1 pM, 100 pM, 10 nM, 1 µM, 100 µM
Incubation Time: 48 hours
Result: Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.
In Vivo

On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity[3].

Molecular Weight

662.68

Formula

C₃₃H₄₂O₁₄

CAS No.

106500-25-8

SMILES
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Keywords:

Azadirachtin BParasitePhosphataseInfluenza VirusALPinsecticidalazadirachtinnematocidalanticancerosteogenicRunX-2OCNanti-inflammatoryantiviralInhibitorinhibitorinhibit

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Azadirachtin B
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